Date: 26 November 2013
Secondary metabolites trivial name – territrem A
Copyright: n/a
Notes:
Species: A. terreusSystematic name: 4H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-9-(7-methoxy-1,3-benzodioxo-5-yl)-4,4,6a,12b-tetramethyl-, (4aR,6aR,12aS,12bS)- 4H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-1,11(5H)-dione, 4a,6,6a,12,12a,1Molecular formulae: C28H30O9Molecular weight: 510.532Chemical abstracts number: 70407-19-1Selected references: Ling KH, Yang CK, Peng FT. Territrems, tremorgenic mycotoxins of Aspergillus terreus.Appl Environ Microbiol. 1979 Mar;37(3):355-7. Ling KH, Liou HH, Yang CM, Yang CK. Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem C from Aspergillus terreus. Appl Environ Microbiol. 1984 Jan;47(1):98-100.Toxicity: A tremorgenic mycotoxin with an intraperitoneal LD50 in mice of 15 to 19 mg/kg body-weight. mouse LD50 intraperitoneal 17600ug/kg (17.6mg/kg) Applied and Environmental Microbiology. Vol. 47, Pg. 98, 1984.
Images library
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Title
Legend
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Conidial head and brown conidia in a section of a fungus ball caused by Aspergillus niger (H&E, x 400).
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Double diffusion test for aspergillosis. Central well contains Aspergillus fumigatus antigen and wells in the top and bottom contain control antiserum.
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Allergic Bronchocentric Granulomatosis. low power. Sections show muscle, lung with acute inflammation and evidence of organisation with early fibrosis. The bronchial wall can be seen with chronic inflammation and many eosinophils.There is a thickened basement membrane. No definite granulomata are seen.
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Allergic Bronchocentric Granulomatosis. Sections show muscle, lung with acute inflammation and evidence of organisation with early fibrosis. The bronchial wall can be seen with chronic inflammation and many eosinophils.There is a thickened basement membrane. No definite granulomata are seen.
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Allergic Bronchocentric Granulomatosis. Higher power. Sections show muscle, lung with acute inflammation and evidence of organisation with early fibrosis. The bronchial wall can be seen with chronic inflammation and many eosinophils.There is a thickened basement membrane. No definite granulomata are seen.
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Allergic Bronchocentric Granulomatosis. Higher power. Sections show muscle, lung with acute inflammation and evidence of organisation with early fibrosis. The bronchial wall can be seen with chronic inflammation and many eosinophils.There is a thickened basement membrane. No definite granulomata are seen.
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Allergic Bronchocentric Granulomatosis. Low power. Sections show muscle, lung with acute inflammation and evidence of organisation with early fibrosis. The bronchial wall can be seen with chronic inflammation and many eosinophils.There is a thickened basement membrane. No definite granulomata are seen.
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Allergic Bronchopulmonary Aspergillosis (ABPA). PT JC
CXR prior to bronchoscopy had shown an opacity just superior to the right hilum, which was felt to represent possibly a fungal plug. Patient was therefore bronchoscoped.
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Secondary metabolites, Structural diagram. Trivial name – 2-hydroxy-3-methyl-1,4-benzoquinone
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Secondary metabolite structure: trivial name – 13-O-Methylviriditin
