Double diffusion test for aspergillosis. Central well contains Aspergillus fumigatus antigen and wells in the top and bottom contain control antiserum.
Images supplied by LC Severo, with the help of AC Pasqualotto, at Santa Casa Complexo Hospitalar, Porto Alegre, Brazil.
The three peripherals wells with precipitin bands contain sera from patients with A. fumigatus fungus ball (FB). More bands present in the upper right cases is characteristic of FB. The well in the bottom left position is negative.
Invasive pulmonary aspergillosis is most commonly seen in immunocompromised patients. Besides, skin lesions may also develop due to invasive aspergillosis in those patients. A 49-year-old male patient was diagnosed with acute myeloid leukemia.
The patient developed bullous and zosteriform lesions on the skin after the 21st day of hospitalization. The skin biopsy showed hyphae. Disseminated skin aspergillosis was diagnosed to the patient.
Voricanazole treatment was initiated. The patient was discharged once the lesions started to disappear.