Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – xanthomegnin
Copyright: n/a
Notes:
Species: A. melleus, A. ochraceus, A. sulphureusSystematic name: (8,8′-Bi-1H-naphtho(1,2-c)pyran)-1,1′,7,7′,10,10′-hexone, 3,3′,4,4′-tetrahydro-6,6′-dihydroxy-9,9′-dimethoxy-3,3′-dimethyl-, (3R,3’R)- (8CI) (8,8′-BI-1H-NAPHTHO(2,3-c)PYRAN)-1,1′,6,6′,9,9′-HEXONE, 3,3′,4,4′-TETRAHYDRO-10, (8,8′-Bi-1H-naphtho(2,3-c)pyranMolecular formulae: C30H22O12Molecular weight: 574.488Chemical abstracts number: 1685-91-2Selected references: Durley RC, MacMillan J, Simpson TJ, Glen AT, Turner WB. Fungal products. Part XIII. Xanthomegnin, viomellin, rubrosulphin, and viopurpurin, pigments from Aspergillus sulphureus and Aspergillus melleus. J Chem Soc [Perkin 1]. 1975;(2):163-9. Stack ME, Mislivec PB. Production of xanthomegnin and viomellein by isolates of Aspergillus ochraceus, Penicillium cyclopium, and Penicillium viridicatum. Appl Environ Microbiol. 1978 Oct;36(4):552-4.Toxicity: Doses of 448 mg/kg body-weight in mice caused symptoms of liver damage including jaundice, necrotising cholangitis and other histological alterations. Robbers JE, Hong S, Tuite J, Carlton WW. Production of xanthomegnin and viomellein by species of Aspergillus correlated with mycotoxicosis produced in mice. Appl Environ Microbiol. 1978 Dec;36(6):819-23.
Images library
-
Title
Legend
-
Saggital section of the vertebral column of a dog with discospondylitis as part of disseminated aspergillosis due to A. terreus
-
Discospondylitis – Radiograph of thoracolumbar vertebrae of a 2 year old, female German shepherd dog with disseminated aspergillosis demonstrating discospondylitis of T13-L1.
-
Wasting and paraplegia – A 2 year old, male German shepherd dog with disseminated aspergillosis due to A. terreus. The marked loss of condition of this dog occurred within two months of initial diagnosis.
-
A 2 year old, female German shephered dog with disseminated aspergillosis due to A. terreus. There is muscle wasting and paraplegia due to discospondylitis involving T13-L1.
-
Draining sinus tract on left forelimb of a 4 year old, female Dalmatian with disseminated aspergillosis. There was an underlying osteomyelitis of distal humerus from which A. terreus was cultured.
-
Aspergillus sinusitis in a dog. Long nosed dogs are at relatively high risk of Aspergillus sinusitis as shown in this example.
-
English Pointer with nasal aspergillosis. Gram stained cytological smear of material obtained from the frontal sinus of a 7 year old English Pointer with nasal aspergillosis. This infection was caused by Aspergillus fumigatus. Magnification x 200.
-
Domestic crossbred cat with disseminated aspergillosis. KOH preparation of material obtained from thoracotomy of a 3 year old domestic crossbred cat with invasive Aspergillus fumigatus infection. The cat had marked enlargement of the hilar lymph nodes that resulted in a partial tracheal obstruction. This preparation was made from portions of the hilar lymph node resected at thoracotomy. Magnification x 132.
-
Rottweiler treated with indwelling plastic tubes. Photograph of a Rottweiler crossbred dog treated with indwelling plastic tubes placed surgically into the nasal cavity and frontal sinuses.
-
Nasal aspergillosis in an English Pointer. Photograph of an English Pointer with nasal aspergillosis
Nasal aspergillosis in an English Pointer. Photograph of an English Pointer with nasal aspergillosis
