Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – viomellein
Copyright: n/a
Notes:
Species: A. melleus, A. ochraceusSystematic name: (8,8′-BI-1H-NAPHTHO(2,3-c)PYRAN)-1,1′,6,9-TETRONE, 3,3′,4,4′-TETRAHYDRO-7,7′-DIM (8,8′-Bi-1H-naphtho(2,3-c)pyran)-1,1′,6,9-tetrone, 3,3′,4,4′-tetrahydro-7,7′-dimethoxy-3,3′-dimethyl-9′,10,10′-trihydroxy-, (R-(R*,R*))-Molecular formulae: C30H24O11Molecular weight: 560.505Chemical abstracts number: 55625-78-0Selected references: Stack ME, Mislivec PB. Production of xanthomegnin and viomellein by isolates of Aspergillus ochraceus, Penicillium cyclopium, and Penicillium viridicatum. Appl Environ Microbiol. 1978 Oct;36(4):552-4. Filtenborg O, Frisvad JC, Svendsen JA. Simple screening method for molds producing intracellular mycotoxins in pure cultures. Appl Environ Microbiol. 1983 Feb;45(2):581-5. Robbers JE, Hong S, Tuite J, Carlton WW. Production of xanthomegnin and viomellein by species of Aspergillus correlated with mycotoxicosis produced in mice. Appl Environ Microbiol. 1978 Dec;36(6):819-23.Toxicity: Causes hepatic and renal damage in animals and associated with porcine nephropathy together with ochratoxins
Images library
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Title
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Conidial head and brown conidia in a section of a fungus ball caused by Aspergillus niger (H&E, x 400).
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Double diffusion test for aspergillosis. Central well contains Aspergillus fumigatus antigen and wells in the top and bottom contain control antiserum.
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Allergic Bronchocentric Granulomatosis. low power. Sections show muscle, lung with acute inflammation and evidence of organisation with early fibrosis. The bronchial wall can be seen with chronic inflammation and many eosinophils.There is a thickened basement membrane. No definite granulomata are seen.
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Allergic Bronchocentric Granulomatosis. Sections show muscle, lung with acute inflammation and evidence of organisation with early fibrosis. The bronchial wall can be seen with chronic inflammation and many eosinophils.There is a thickened basement membrane. No definite granulomata are seen.
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Allergic Bronchocentric Granulomatosis. Higher power. Sections show muscle, lung with acute inflammation and evidence of organisation with early fibrosis. The bronchial wall can be seen with chronic inflammation and many eosinophils.There is a thickened basement membrane. No definite granulomata are seen.
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Allergic Bronchocentric Granulomatosis. Higher power. Sections show muscle, lung with acute inflammation and evidence of organisation with early fibrosis. The bronchial wall can be seen with chronic inflammation and many eosinophils.There is a thickened basement membrane. No definite granulomata are seen.
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Allergic Bronchocentric Granulomatosis. Low power. Sections show muscle, lung with acute inflammation and evidence of organisation with early fibrosis. The bronchial wall can be seen with chronic inflammation and many eosinophils.There is a thickened basement membrane. No definite granulomata are seen.
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Allergic Bronchopulmonary Aspergillosis (ABPA). PT JC
CXR prior to bronchoscopy had shown an opacity just superior to the right hilum, which was felt to represent possibly a fungal plug. Patient was therefore bronchoscoped.
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Secondary metabolites, Structural diagram. Trivial name – 2-hydroxy-3-methyl-1,4-benzoquinone
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Secondary metabolite structure: trivial name – 13-O-Methylviriditin
