Secondary metabolites, 3D structure: Trivial name – Malformin C

Date: 26 November 2013

  • Malforminweb3D

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Secondary metabolites, 3D structure: Trivial name – Malformin C

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Notes:

Species: A. nigerSystematic name: 2-[2-[2-[2-(2-aminopropanoylamino)-3-sulfanylidene-propanoyl]amino-3-methyl-butanoyl]amino-4-methyl-pent-4-enoyl]amino-4-methyl-pentanethioic acidMolecular formulae: C23H39N5O5S2Molecular weight: 529.718Chemical abstracts number: 59926-78-2Selected references: KOBBE B ; CUSHMAN M ; WOGAN GN ; DEMAIN AL. Production and antibacterial activity of malformin C, a toxic metabolite of Aspergillus niger. APPL ENVIRON MICROBIOL; 33 (4). 1977 996-997Toxicity: mouse LD50 intraperitoneal 900ug/kg (0.9mg/kg) CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 309, 1980.

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Showing 10 posts of 2574 posts found.

  • Title

    Legend

  • Hickman Line

    Hickman line

  • Percutaneous lung biopsy

    Percutaneous biopsy needle is seen vertically above the back

    Percutaneous biopsy needle is seen vertically above the back

  • Hickman line

    Chest Xray showing the normal course of a Hickman line

    Chest Xray showing the normal course of a Hickman line

  • PtDS2 – Repeated chest infections halted by itraconazole in ABPA and bronchiectasis

    PtDS2 –Repeated chest infections arrested by itraconazole therapy in ABPA and bronchiectasis

    DS2 developed asthma age 24 and now aged 62. From about age 30 she started getting repeated chest infections and a few years later ABPA and bronchiectasis was diagnosed. Infections continued requiring multiple courses of antibiotics annually. At one point DS2 developed a pneumothorax, possibly because of excess coughing. She has chronic rhinitis and mannose binding lectin deficiency. In May 2011, she started itraconazole therapy, and has needed no antibiotic courses for her chest since. Her rhinitis with sinusitis occasionally bothers her. She is delighted to have gone 18 months with no chest infections.

    Image A., Image B., Image C.

  • Sputum typical of bronchiectasis

    Image 2

    IMG_2194med

  • Sputum typical of bronchiectasis

    Image 1

    IMG_2195med

  • Airways (tracheobronchial)

    Aspergillus hyphae (arrow) in the lumen without invasion of the necrotic bronchial wall (*) (Nicod 2001).

    Aspergillus hyphae (arrow) in the lumen without invasion of the necrotic bronchial wall (*) (Nicod 2001).

  • Airways (tracheobronchial)

    fibrinonecrotic material (arrow) from the airway shown in A, with subocclusion of the bronchial lumen (*)

    fibrinonecrotic material (arrow) from the airway shown in A, with subocclusion of the bronchial lumen (*);

  • Airways (tracheobronchial)

    Fibrinous or pseudomembranous bronchitis (arrow) with subocclusion of the airways (* indicates subocclusion of the airways by pseudomembranes)

    Fibrinous or pseudomembranous bronchitis (arrow) with subocclusion of the airways (* indicates subocclusion of the airways by pseudomembranes);

  • Airways (tracheobronchial)

    Bronchoscopic biopsy demonstrated septate hyphae with branching at 45o (methenamine silver stain ×400).

    Bronchoscopic biopsy demonstrated septate hyphae with branching at 45o (methenamine silver stain ×400).