Secondary metabolites, 3D structure: Trivial name – Citraconic anhydride

Date: 26 November 2013

Secondary metabolites, 3D structure: Trivial name – Citraconic anhydride

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Notes:

Species: A. wentiiSystematic name: 2,5-Furandione, 3-methyl-Molecular formulae: C5H4O3Molecular weight: 112Chemical abstracts number: 616-02-4Selected references: Secondary mold metabolites. IX. Structure of a new bianthrone and of three new secoanthraquinones from Aspergillus wentii Wehmer. Assante, Gemma; Camarda, Lorenzo; Nasini, Gianluca. Ist. Patol. Veg., Univ. Milano, Milan, Italy. Gazzetta Chimica Italiana (1980), 110(11-12), 629-31. CODEN: GCITA9 ISSN: 0016-5603. Journal written in English. CAN 94:153102 AN 1981:153102 CAPLUS


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  • Percutaneous biopsy needle is seen vertically above the back

    Percutaneous biopsy needle is seen vertically above the back

  • Chest Xray showing the normal course of a Hickman line

    Chest Xray showing the normal course of a Hickman line

  • PtDS2 –Repeated chest infections arrested by itraconazole therapy in ABPA and bronchiectasis

    DS2 developed asthma age 24 and now aged 62. From about age 30 she started getting repeated chest infections and a few years later ABPA and bronchiectasis was diagnosed. Infections continued requiring multiple courses of antibiotics annually. At one point DS2 developed a pneumothorax, possibly because of excess coughing. She has chronic rhinitis and mannose binding lectin deficiency. In May 2011, she started itraconazole therapy, and has needed no antibiotic courses for her chest since. Her rhinitis with sinusitis occasionally bothers her. She is delighted to have gone 18 months with no chest infections.

    Image A., Image B., Image C.

  • Aspergillus hyphae (arrow) in the lumen without invasion of the necrotic bronchial wall (*) (Nicod 2001).

    Aspergillus hyphae (arrow) in the lumen without invasion of the necrotic bronchial wall (*) (Nicod 2001).

  • fibrinonecrotic material (arrow) from the airway shown in A, with subocclusion of the bronchial lumen (*)

    fibrinonecrotic material (arrow) from the airway shown in A, with subocclusion of the bronchial lumen (*);

  • Fibrinous or pseudomembranous bronchitis (arrow) with subocclusion of the airways (* indicates subocclusion of the airways by pseudomembranes)

    Fibrinous or pseudomembranous bronchitis (arrow) with subocclusion of the airways (* indicates subocclusion of the airways by pseudomembranes);

  • Bronchoscopic biopsy demonstrated septate hyphae with branching at 45o (methenamine silver stain ×400).

    Bronchoscopic biopsy demonstrated septate hyphae with branching at 45o (methenamine silver stain ×400).