Date: 26 November 2013
Copyright: n/a
Notes:
Dr Jenny Bartholomew is a Research Associate in the Institute of Inflammation and Repair, University of Manchester. A Manchester graduate – she formerly worked as a University Lecturer at Monash University, Melbourne for four years where she undertook research into the immunology of connective tissue damage and repair in rheumatoid arthritis, identifying TNF alpha in inflamed cartilage in an animal model of arthritis.
On returning to Manchester she moved to Christie Hospital, Manchester as a Research Fellow and University teacher where her main research interests were studying the immunological responses to human papillomavirus (HPV 16/18) in cervical cancer. Using recombinant vaccinia virus to express viral proteins from HPV, the major oncoproteins from HPV were studied and used in the development of the cervical cancer vaccine.
For the last 12 years she has been involved in Aspergillus research, providing clinical and scientific information to patients, doctors and scientists, she manages and publishes the Aspergillus website. This is a complex educational resource providing the latest research, technology and information for a wide diversity of users. She has a particular interest in video media and produces a broad range of video interviews from patients and clinics for educational use.
She is now engaged in global health programme. Jenny has launched the LIFE (Leading International Fungal Education) programme commencing with a public engagement and awareness project in 2012, combining Science with Art, aimed at educating young people about harmful fungi.
This was followed by the LIFE online resource (http://life-worldwide.org) for health care professionals encompassing all fungi, the infections they cause, diagnosis and treatments. This resource has a news flow about global health and is targeting global education about fungi and serious infections they can cause. The site is now being translated into Spanish and other languages will follow soon. She launched the Global Action Fund for Fungal Infection site (http://gaffi.org) in July 2013 – GAFFI is a foundation based in Geneva, focused on advocacy for access to diagnostics and treatment in every country.
Aspergillus website, Life worldwide organisation, GAFFI , National Aspergillosis Centre, Mycology Reference Laboratory and Fungal Infection Trust.
Some of my Publications:
- Bartholomew, J S, J M Evanson and DE Woolley . Rheumatol. Int., II: 37-40, 1991 Serum IgE Anti-cartilage Collagen Antibodies in Rheumatoid Patients.
- Bartholomew,J S,J M Evanson and DE Woolley . Allergy Digests, 2: 30-31, 1992 Collagen Specific IgE Antibodies in Rheumatoid Patients.
- Stacey,S N, J S Bartholomew, A Ghosh, P L Stern, M Mackett and J R Arrand. J.Gen. Vir., 73: 2337-2345, 1992 Expression of human papillomavirus type 16 E6 protein by recombinant baculovirus and use for detection of anti-E6 antibodies in human sera.
- Stacey,S N, A Ghosh, J S Bartholomew, R W Tindle, P L Stern, M Mackett and J R Arrand. J. Med. Virol., 40: 14-21, 1993. Expression of human papillomavirus type 16 E7 protein by recombinant baculovirus and use for the detection of E7 antibodies in sera from cervical carcinogen patients.
- Bartholomew,JS, S N Stacey, B Coles, D Burt, I R Arrand and P L Stern. European Journal of Immunology, 24: 3175-3179, 1994 Identification of a naturally processed HLA-A0201 restricted viral peptide from cells expressing human papillomavirus type 16 E6 oncoprotein.
- Bartholomew J and P L Stern.
In: Modulation of MHC Antigen Expression and Disease. Eds E G Blair, D J Maudsley and C P Pringle, 233-250, 1994 MHC expression in HPV associated cervical cancer. - Ellis JRM, P I Keating, J Baird, E F Hounsell, D V Renouf, M Rowe, D Hopkins, M F Duggan-Keen, J.S Bartholomew, L S Young and P L Stern. Nature Medicine, 1,464-470, 1995 An HP V 16 variant is associated with cervical carcinoma in HLA-B7 positive women.
- Bartholomew,JS, S. Glenville, S. Sarkar, D.I. Burt, M.A. Stanley, F. Ruiz-Cabens, J. Chengang, F. Garrido and P .L. Stern. Cancer Res. March 1, 1997. Integration of high-risk human papillomavirus DNA is linked to the down-regulation of Class I Human leukocyte antigens by steroid hormones in cervical tumour cells.
- Brady CS. Bartholomew JS. Burt DJ. Duggan-Keen MF. Glenville S. Telford N. Little AM. Davidson JA. Jimenez P. Ruiz-Cabello F. Garrido F. Stern PL.
Tissue Antigens. 55(5):401-11, 2000 May. Multiple mechanisms underlie HLA dysregulation in cervical cancer. - Fungi: friends or foes? Biological Sciences Review 17(1) 24-28, 2004
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Mabey Gilsenan JE, Atherton G, Bartholomew J, Giles PF, Attwood TK, Denning DW, Bowyer P.
Aspergillus genomes and the aspergillus cloud Nucleic Acids Res. 2009 Jan;37(Database issue):D509-14. Epub 2008 Nov 27
E-mail: jennifer.bartholomew@manchester.ac.uk
Images library
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Title
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This 24-year-old male with AML on chemotherapy developed recent onset fever and cough. B- Representative section of High Resolution CT shows centri-lobular nodules, ‘tree-in-bud’ appearance consistent with bronchogenic spread of disease.
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This 24-year-old male with AML on chemotherapy developed recent onset fever and cough. A: Chest radiograph showing patchy air space consolidation involving both lungs.
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This man with severe chronic fibrosing alveolitis underwent a single left lung transplant at the end of November 2004. Postoperatively he developed reperfusion pulmonary oedema and was difficult to ventilate. He also developed acute renal failure requiring haemodialysis/haemofiltration which corrected his fluid overload and rising creatinine.Rejection was prevented with cyclosporin, mycophenolate and a decreasing dose of methylprednisolone. Cardiovascular problems identified mild pulmonary anastomostic stenosis with a 5% pressure gradient. He had a tracheostomy about 12 days post transplant. He then developed episodes of hypoxia and increased ventilatory pressures. Several bronchoscopies showed mucus plugging in the trachea and major bronchi. These were aspirated, with improvement of oxygenation. Cultures of one of these plugs grew A. fumigatus. These images show a bronchoscopy view of the trachea and anastomosis. Major obstruction of the airway is visible (70%) distal to the anastomosis which looks healthy. Some evidence of tracheal inflammation is visible.
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The chest x-ray shows a patient who had a left lung transplanted in May 2003 for cryptogenic fibrosing alveolitis, which was diagnosed post-transplant as sarcoidosis.
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Tracheal aspergillosis. Bronchoscopic views of the trachea showing nodules in the trachea that revealed Aspergillus on biopsy. The patient had chronic lymphocytic leukaemia treated with fludarabine and corticosteroids and presented with wheezing and bilateral alveolar shadows.
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Tracheal aspergillosis, Bronchoscopic views of the trachea showing nodules in the trachea that revealed Aspergillus on biopsy. The patient had chronic lymphocytic leukaemia treated with fludarabine and corticosteroids and presented with wheezing and bilateral alveolar shadows.
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Tracheal aspergillosis. Bronchoscopic views of the trachea showing nodules in the trachea that revealed Aspergillus on biopsy. The patient had chronic lymphocytic leukaemia treated with fludarabine and corticosteroids and presented with wheezing and bilateral alveolar shadows.
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Tracheal aspergillosis. Bronchoscopic views of the trachea showing nodules in the trachea that revealed Aspergillus on biopsy. The patient had chronic lymphocytic leukaemia treated with fludarabine and corticosteroids and presented with wheezing and bilateral alveolar shadows.
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Aspergillus tracheobronchitis in a normal child. This figure, drawn in 1890, illustrates the appearances of the trachea and main bronchi at autopsy in a 3 year old child. She had little else wrong at autopsy other than a minor degree of tuberculosis. She is the first recorded case of Aspergillus tracheobronchitis in the literature and illustrates well that this disease can affect previously well non-inimmunocompromised people. The full case is reported in Wheaton SW.
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pt FT. Normal chest radiograph of patient with extensive pseudomembranous Aspergillus tracheobronchitis, 4 days before death.
