Jenny Bartholomew

Date: 26 November 2013

  • jenny2

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Dr Jenny Bartholomew is a Research Associate in the Institute of Inflammation and Repair, University of Manchester.  A Manchester graduate – she formerly worked as a University Lecturer at Monash University, Melbourne for four years where she undertook research into the immunology of connective tissue damage and repair in rheumatoid arthritis, identifying TNF alpha in inflamed cartilage in an animal model of arthritis.
 On returning to Manchester she moved to Christie Hospital, Manchester as a Research Fellow and University teacher where her main research interests were studying the immunological responses to human papillomavirus (HPV 16/18) in cervical cancer. Using recombinant vaccinia virus to express viral proteins from HPV, the major oncoproteins from HPV were studied and used in the development of the cervical cancer vaccine.

For the last 12 years she has been involved in Aspergillus research,  providing clinical and scientific information to patients, doctors and scientists, she manages and publishes the Aspergillus website. This is a complex educational resource providing the latest research, technology and information for a wide diversity of users.  She has a particular interest in video media and produces a broad range of video interviews from patients and clinics for educational use. 
She is now engaged in global health programme. Jenny has launched the LIFE (Leading International Fungal Education) programme commencing with a public engagement and awareness  project in 2012, combining  Science with Art, aimed at educating young people about harmful fungi.
This was followed by the LIFE online resource (http://life-worldwide.org) for health care professionals encompassing all fungi, the infections they cause, diagnosis and treatments. This resource has a news flow about global health and is targeting global education about fungi and serious infections they can cause. The site is now being translated into Spanish and other languages will follow soon.  She launched the Global Action Fund for Fungal Infection site (http://gaffi.org) in July 2013 – GAFFI is a foundation based in Geneva, focused on advocacy for access to diagnostics and treatment in every country.

Aspergillus website, Life worldwide organisation, GAFFI , National Aspergillosis Centre, Mycology Reference Laboratory and Fungal Infection Trust.

Some of my Publications:

  • Bartholomew, J S, J M Evanson and DE Woolley . Rheumatol. Int., II: 37-40, 1991 Serum IgE Anti-cartilage Collagen Antibodies in Rheumatoid Patients.
  • Bartholomew,J S,J M Evanson and DE Woolley . Allergy Digests, 2: 30-31, 1992 Collagen Specific IgE Antibodies in Rheumatoid Patients.
  • Stacey,S N, J S Bartholomew, A Ghosh, P L Stern, M Mackett and J R Arrand. J.Gen. Vir., 73: 2337-2345, 1992 Expression of human papillomavirus type 16 E6 protein by recombinant baculovirus and use for detection of anti-E6 antibodies in human sera.
  • Stacey,S N, A Ghosh, J S Bartholomew, R W Tindle, P L Stern, M Mackett and J R Arrand. J. Med. Virol., 40: 14-21, 1993. Expression of human papillomavirus type 16 E7 protein by recombinant baculovirus and use for the detection of E7 antibodies in sera from cervical carcinogen patients.
  • Bartholomew,JS, S N Stacey, B Coles, D Burt, I R Arrand and P L Stern. European Journal of Immunology, 24: 3175-3179, 1994 Identification of a naturally processed HLA-A0201 restricted viral peptide from cells expressing human papillomavirus type 16 E6 oncoprotein.
  • Bartholomew J and P L Stern. 
    In: Modulation of MHC Antigen Expression and Disease. Eds E G Blair, D J Maudsley and C P Pringle, 233-250, 1994 MHC expression in HPV associated cervical cancer.
  • Ellis JRM, P I Keating, J Baird, E F Hounsell, D V Renouf, M Rowe, D Hopkins, M F Duggan-Keen, J.S Bartholomew, L S Young and P L Stern. Nature Medicine, 1,464-470, 1995 An HP V 16 variant is associated with cervical carcinoma in HLA-B7 positive women.
  • Bartholomew,JS, S. Glenville, S. Sarkar, D.I. Burt, M.A. Stanley, F. Ruiz-Cabens, J. Chengang, F. Garrido and P .L. Stern. Cancer Res. March 1, 1997. Integration of high-risk human papillomavirus DNA is linked to the down-regulation of Class I Human leukocyte antigens by steroid hormones in cervical tumour cells.
  • Brady CS. Bartholomew JS. Burt DJ. Duggan-Keen MF. Glenville S. Telford N. Little AM. Davidson JA. Jimenez P. Ruiz-Cabello F. Garrido F. Stern PL.
    Tissue Antigens. 55(5):401-11, 2000 May. Multiple mechanisms underlie HLA dysregulation in cervical cancer.
  • Fungi: friends or foes? Biological Sciences Review 17(1) 24-28, 2004
  • Mabey Gilsenan JE, Atherton G, Bartholomew J, Giles PF, Attwood TK, Denning DW, Bowyer P.

    Aspergillus genomes and the aspergillus cloud Nucleic Acids Res. 2009 Jan;37(Database issue):D509-14. Epub 2008 Nov 27

E-mail: jennifer.bartholomew@manchester.ac.uk 

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Showing 10 posts of 2574 posts found.

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  • abpa10

  • Bronchocentric granulomatosis

    Further details

    Image G. Patient was a 9 year old girl 5 months post matched unrelated donor (MUD) bone marrow transplantation with T-cell depletion, with reduced respiratory function (dyspnoea), cough and crackles at the bases, without fever. Donor and recipient were CMV antibody negative. 5/10/98.  

    Image A. Lung biopsy - H&E section of right lung showing a large granuloma with some central necrosis, consistent with tuberculosis or an invasive fungal infection. Special stains for acid fast organisms and fungi were negative. - 3/11/98, Image B. Lung biopsy - High power H&E stained section of right lung showing a group of giant cells surrounded by lymphocytes. - 3/11/98 , Image C. Lung biopsy - Low power H&E stained section of right lung showing preservation of a small artery, but destruction of a small bronchus by a granulomatous process. - 3/11/98 , Image D. Lung biopsy - Low power elastin stain of right lung showing preservation of the normal elastin fibres around a small artery, but loss of elastin around a small bronchus, indicating bronchial destruction. - 3/11/98 - , Image E. Chest X-ray showing progression of infiltrates, despite azithomycin and itraconazole. She subsequently responded to large doses of corticosteroids. 3/11/98 , Image F. CT scan showing multiple small nodules of variable size in both lung fields, apparently close to the vascular bundles. 6/10/98 , Image G. Chest X-ray showing bilateral diffuse infiltrates consistent with a miliary disease such as tuberculosis or aspergillosis. 5/10/98.

  • Fluorescence microscopy with A. fumigatus

    Fluorescence microscopy was performed on the same sample as blankophor® staining according to Ruchel R. & Margraf S. 1993, Mycoses 36, 239-242. The artefactual staining of fibres and cellular elements is due to previous drying of the smear and recedes with time.

    patt21

  • A. fumigatus stained with Blankophor®

    A needle biopsy of a solitary round infiltrate found near the thoracic wall in a patient with acute lymphoblastic leukaemia was gram-stained and then treated with an alkaline solution of the whitening agent Blankophor®.

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  • Cerebral aspergillosis

    Medium power view (H&E) of cerebral abscess in which there are hyphae consistent with Aspergillus. Aspergillus fumigatus was grown from adjacent tissue.

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  • Renal aspergillosis

    Medium power view (GMS) of kidney invaded by Aspergillus. The walls of the hyphae stain black. There are plentiful fungal hyphae within two glomeuli and there is also fungal invasion of adjacent cortical interstitial tissue.

    patt7

  • Aspergillus endocarditis

    High power view (H&E) of uniform septate hyphae which show typical diclotomous branding characteristic of Aspergillus taken from mitral valve vegetation in a patient with disseminated aspergillosis. The hyphae are present within a background of fibrinous material.

    patt6

  • Pulmonary aspergillosis

    Medium power view (H&E) of lung tissue in patient with invasive pulmonary aspergillosis in which many of the fungal hyphae are seen in cross section.

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  • patt4

  • Pulmonary aspergillosis

    Medium power view of lung (H&E) in which there is invasion of lung parenchyma by hyphae characteristic of Aspergillus resulting in lung tissue infarction.

    patt3