Secondary metabolites, Stucture diagram. Trivial name - 2-Methyl-1,4-benzoquinone 5,6-epoxide

Date: 26 November 2013

Secondary metabolites, Stucture diagram. Trivial name – 2-Methyl-1,4-benzoquinone 5,6-epoxide

Notes:

Species: A. terreusSystematic name: 7-Oxabicyclo[4.1.0]hept-3-ene-2,5-dione, 3-methyl-Molecular formulae: C7H6O3Molecular weight: 138Chemical abstracts number: 15254-70-3PubChem URL: Go to PubChem linkSelected references Subramanian, T.; Namasivayam, K. Mohan; Shanmugasundaram, E. R. B. (Biochem. Lab., Univ. Madras, Madras, India). Proc. Indian Acad. Sci., Sect. B, 87B(7), 177-9 (English) 1978.

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Aspergillus fumigatus Fresen

Aspergillus fumigatus Fresen
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920

Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
Aspergillus cretensis

Conidia
Aspergillus cretensis

Seven-day-old cultures on CYA
Aspergillus cretensis

Conidiophores
Aspergillus clavatus

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Cerebral aspergillosis – CT scans, CLL patient DS.

Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.

Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.

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