Date: 26 November 2013
Secondary metabolites, strucure diagram: Trivial name – physcionanthrone B
Copyright: n/a
Notes:
Species: A. chevalieriSystematic name: 1,8-Dihydroxy-3-methoxy-6-methylanthrone 9(10H)-Anthracenone, 1,8-dihydroxy-3-methoxy-6-methyl-Molecular formulae: C16H14O4Molecular weight: 270.28Chemical abstracts number: 3571-31-1Selected references: Bachmann M, Blaser P, Luthy J, Schlatter C. J Environ Pathol Toxicol Oncol. 1992 Mar-Apr;11(2):49-52. Toxicity and mutagenicity of anthraquinones from Aspergillus chevalieri.Toxicity: mouse LD50 intraperitoneal 2000ug/kg (2mg/kg) EFFECT: GASTROINTESTINAL: OTHER CHANGES Journal of Agricultural and Food Chemistry. Vol. 27, Pg. 1342, 1979
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Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
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Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.
Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.
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![Asp[1]niger](https://www.aspergillus.org.uk/wp-content/uploads/2013/11/Asp1niger-150x150.gif "Asp[1]niger")
