Secondary metabolites, strucure diagram: Trivial name – physcionanthrone B

Date: 26 November 2013

Secondary metabolites, strucure diagram: Trivial name – physcionanthrone B

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Notes:

Species: A. chevalieriSystematic name: 1,8-Dihydroxy-3-methoxy-6-methylanthrone 9(10H)-Anthracenone, 1,8-dihydroxy-3-methoxy-6-methyl-Molecular formulae: C16H14O4Molecular weight: 270.28Chemical abstracts number: 3571-31-1Selected references: Bachmann M, Blaser P, Luthy J, Schlatter C. J Environ Pathol Toxicol Oncol. 1992 Mar-Apr;11(2):49-52. Toxicity and mutagenicity of anthraquinones from Aspergillus chevalieri.Toxicity: mouse LD50 intraperitoneal 2000ug/kg (2mg/kg) EFFECT: GASTROINTESTINAL: OTHER CHANGES Journal of Agricultural and Food Chemistry. Vol. 27, Pg. 1342, 1979


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  • Culture plates on different media. A Colonies on CZ at 24oC, B on CYA at 20oC C on SAB at 37oC, D on CYA at 24oC

    persiicolonies

  • D Sinusitis radiology with fluid level

  • C Bronchiectasis white cell scan (right) – left shows a normal scan for comparison

  • B Bronchogram showing bronchiectasis

  • A Bronchogram showing saccular bronchiectasis

  • Mucous containing Charcot-Leyden crystals, stained with H & EA 57 year old woman presented with breathlessness. She had a history of mild asthma for which she occasionally took salbutamol inhaler puffs. The patient underwent a pneumonectomy because of the severity of her disease process, and uncertainty about the diagnosis, prior to serology results being obtained.Serology showed an IgE of 2600, with a strongly positive Aspergillus RAST test and weakly positive Aspergillus precipitins. Material re