Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Versiconal hemiacetal acetate (2)
Copyright: n/a
Notes:
Species: A. parasiticusSystematic name: Anthra[1,2-b]furan-6,11-dione, 3-[2-(acetyloxy)ethyl]-2,3-dihydro-2,4,8,10-tetrahydroxy-Molecular formulae: C20H16O9Molecular weight: 400Chemical abstracts number: 62886-46-8Selected references: Structure and carbon-13 nuclear magnetic resonance assignments of versiconal acetate, versiconol acetate, and versiconol, metabolites from cultures of Aspergillus parasiticus treated with dichlorvos. Steyn, Pieter S.; Vleggaar, Robert; Wessels, Philippus L.; Cole, Richard J.; Scott, De Buys. Natl. Chem. Res. Lab., Counc. Sci. Ind. Res., Pretoria, S. Afr. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1979), (2), 451-9.
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Nodules and areas of atelectasis are seen at both bases. He later died.
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It is clearly a relatively small cavitary lesion, and the patient was almost asymptomatic. This response was a ‘stable’ response. The patient was included in the report Denning DW, Lee JY, Hostetler JS, Pappas P, Kauffman CA, Dewsnup DH, Galgiani JN, Graybill JR, Sugar AM, Catanzaro A, Gallis H, Perfect JR, Dockery B, Dismukes WE, Stevens DA, NIAID Mycoses Study Group multicenter trial of oral itraconazole therapy of invasive aspergillosis. Am J Med 1994; 97: 135-144.
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Well demarcated pulmonary infarction is well seen in this close-up of the lung at autopsy in a patient with histologically confirmed invasive aspergillosis. Angio invasion is characteristic of invasive aspergillosis, is associated with a worse prognosis, but is not always seen.
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This 83 year old man presented with weight loss to a lung cancer clinic in mid 2003.
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