Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Tubingensin B
Copyright: n/a
Notes:
Species: A. tubingensisSystematic name: 1H-7,14b-Ethanobenzo[3,4]cyclohepta[1,2-b]carbazol-1-ol, 2,3,4,4a,5,6,7,9-octahydro-4,4a-dimethyl-7-(1-methylethyl)-, (1a,4a,4aa,7a,14bb)-(-)- (9CI)Molecular formulae: C28H35NOChemical abstracts number: 126663-32-9Selected references: TePaske, Mark R.; Gloer, James B.; Wicklow, Donald T.; Dowd, Patrick F. The structure of tubingensin B: a cytotoxic carbazole alkaloid from the sclerotia of Aspergillus tubingensis. Tetrahedron Letters (1989), 30(44), 5965-8. CODEN: TELEAY ISSN:
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Drug rashes: Drug interactions between steroids and anti-fungal drugs – (ecchymosis)
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Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.
Courtesy of Dr D Denning, Wythenshawe Hospital, Manchester.(© Fungal Research Trust),
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Micrographs of A. niger conidia & conidial heads provided by Amaliya Stepanova, Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. terreus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Patients has history of ABPA complicating long standing asthma. His total IgE has fluctuated between 2,200 and 4,600 KU/L, his Aspergillus IgE between 36.3 and 65.4 kAU/L and Aspergillus IgG from 87-154 mg/L. He has been taking long term itraconazole.
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