Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Tubingensin B
Copyright: n/a
Notes:
Species: A. tubingensisSystematic name: 1H-7,14b-Ethanobenzo[3,4]cyclohepta[1,2-b]carbazol-1-ol, 2,3,4,4a,5,6,7,9-octahydro-4,4a-dimethyl-7-(1-methylethyl)-, (1a,4a,4aa,7a,14bb)-(-)- (9CI)Molecular formulae: C28H35NOChemical abstracts number: 126663-32-9Selected references: TePaske, Mark R.; Gloer, James B.; Wicklow, Donald T.; Dowd, Patrick F. The structure of tubingensin B: a cytotoxic carbazole alkaloid from the sclerotia of Aspergillus tubingensis. Tetrahedron Letters (1989), 30(44), 5965-8. CODEN: TELEAY ISSN:
Images library
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Title
Legend
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Necrotic lung tissue in culture
Af=Colony of Aspergillus fumigatus
B=bacterial colonies
L=lung tissue
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A photograph of part of the upper lung lobe of an immunosuppressed patient. The lung tissue shows extenive areas of necrosis due to invasive colonisation.
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A photograph of a cavity in the upper lobe of the lung of a patient with ankylosing spondylitis. Such cavitation,which may be confused with prior tuberculosis, can follow fibrosis.
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Plugs stained with Methenamine/silverActively growing mycelia of the fungus are a deep brown/black. Counterstaining shows the dense mucus of the plugs as predominantly orange.
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Sputum from an asthmatic patient showing plugs(casts). The development of plugs coincided with an increased prevalence and severity of episodes of asthma
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microscopic characters Conidiophore stipes(C)1300-2800um long:Vesicles(V)40-70um wide,clavate:Phialides(Ph) uniseriate:Conidia(Con)3.5-4.0um long,smooth walled.
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microscopic characters Conidiophore stipes(C)225-350um arising from hyphae(Hy):Vesicles(Ves)15-25um wide:Phialides(Ph)uniseriate:Conidia(Con)2.4-3.0um spherical to ovoid,roughened.
