Secondary metabolites, structure diagram: Trivial name – tryptoquivaline J

Date: 26 November 2013

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Secondary metabolites, structure diagram: Trivial name – tryptoquivaline J

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Species: A. fumigatusSystematic name: Spiro[furan-2(5H),9′-[9H]imidazo[1,2-a]indole]-3′,5(2’H)-dione, 1′,3,4,9’a-tetrahydro-2′-methyl-4-(4-oxo-3(4H)-quinazolinyl)-, [2’S-[2’a,9’b(S*),9’aa]]-Molecular formulae: C22H18N4O4Molecular weight: 402.403Chemical abstracts number: 66212-51-9Selected references: Yamazaki, Mikio; Fujimoto, Haruhiro; Okuyama, Emi (Res. Inst. Chemobiodyn., Chiba Univ., Chiba, Japan). Chem. Pharm. Bull., 26(1), 111-17 (English) 1978.SECONDARY METABOLITES MYCOTOXINS PRODUCED BY FUNGI COLONIZING CEREAL GRAIN IN STORAGE STRUCTURE AND PROPERTIES GOLINSKI P CHELKOWSKI, J. (ED.). DEVELOPMENTS IN FOOD SCIENCE, VOL. 26. CEREAL GRAIN: MYCOTOXINS, FUNGI AND QUALITY IN DRYING AND STORAGE. XXII+607P. ELSEVIER SCIENCE PUBLISHERS B.V.: AMSTERDAM, NETHERLANDS; (DIST. IN THE USA AND CANADA BY ELSEVIER SCIENCE PUBLISHING CO., INC.: NEW YORK, NEW YORK, USA). ILLUS. MAPS. ISBN 0-444-88554-4.; 0 (0). 1991. 355-403.

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  • abpa10

  • Bronchocentric granulomatosis

    Further details

    Image G. Patient was a 9 year old girl 5 months post matched unrelated donor (MUD) bone marrow transplantation with T-cell depletion, with reduced respiratory function (dyspnoea), cough and crackles at the bases, without fever. Donor and recipient were CMV antibody negative. 5/10/98.  

    Image A. Lung biopsy - H&E section of right lung showing a large granuloma with some central necrosis, consistent with tuberculosis or an invasive fungal infection. Special stains for acid fast organisms and fungi were negative. - 3/11/98, Image B. Lung biopsy - High power H&E stained section of right lung showing a group of giant cells surrounded by lymphocytes. - 3/11/98 , Image C. Lung biopsy - Low power H&E stained section of right lung showing preservation of a small artery, but destruction of a small bronchus by a granulomatous process. - 3/11/98 , Image D. Lung biopsy - Low power elastin stain of right lung showing preservation of the normal elastin fibres around a small artery, but loss of elastin around a small bronchus, indicating bronchial destruction. - 3/11/98 - , Image E. Chest X-ray showing progression of infiltrates, despite azithomycin and itraconazole. She subsequently responded to large doses of corticosteroids. 3/11/98 , Image F. CT scan showing multiple small nodules of variable size in both lung fields, apparently close to the vascular bundles. 6/10/98 , Image G. Chest X-ray showing bilateral diffuse infiltrates consistent with a miliary disease such as tuberculosis or aspergillosis. 5/10/98.

  • Fluorescence microscopy with A. fumigatus

    Fluorescence microscopy was performed on the same sample as blankophor® staining according to Ruchel R. & Margraf S. 1993, Mycoses 36, 239-242. The artefactual staining of fibres and cellular elements is due to previous drying of the smear and recedes with time.

    patt21

  • A. fumigatus stained with Blankophor®

    A needle biopsy of a solitary round infiltrate found near the thoracic wall in a patient with acute lymphoblastic leukaemia was gram-stained and then treated with an alkaline solution of the whitening agent Blankophor®.

    patt20

  • Cerebral aspergillosis

    Medium power view (H&E) of cerebral abscess in which there are hyphae consistent with Aspergillus. Aspergillus fumigatus was grown from adjacent tissue.

    patt9

  • Renal aspergillosis

    Medium power view (GMS) of kidney invaded by Aspergillus. The walls of the hyphae stain black. There are plentiful fungal hyphae within two glomeuli and there is also fungal invasion of adjacent cortical interstitial tissue.

    patt7

  • Aspergillus endocarditis

    High power view (H&E) of uniform septate hyphae which show typical diclotomous branding characteristic of Aspergillus taken from mitral valve vegetation in a patient with disseminated aspergillosis. The hyphae are present within a background of fibrinous material.

    patt6

  • Pulmonary aspergillosis

    Medium power view (H&E) of lung tissue in patient with invasive pulmonary aspergillosis in which many of the fungal hyphae are seen in cross section.

    patt5

  • patt4

  • Pulmonary aspergillosis

    Medium power view of lung (H&E) in which there is invasion of lung parenchyma by hyphae characteristic of Aspergillus resulting in lung tissue infarction.

    patt3