Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – tryptoquivaline H
Copyright: n/a
Notes:
Species: A. fumigatusSystematic name: Spiro[furan-2(5H),9′-[9H]imidazo[1,2-a]indole]-3′,5(2’H)-dione, 1′,3,4,9’a-tetrahydro-1′-hydroxy-2′-methyl-4-(4-oxo-3(4H)-quinazolinyl)-, (2S,2’S,4S,9’aS)-Molecular formulae: C22H18N4O5Molecular weight: 418.402Chemical abstracts number: 61949-67-5Selected references: Yamazaki, Mikio; Fujimoto, Haruhiro; Okuyama, Emi (Res. Inst. Chemobiodynamics, Chiba Univ., Chiba, Japan). Tetrahedron Lett., (33), 2861-4 (English) 1976.SECONDARY METABOLITES MYCOTOXINS PRODUCED BY FUNGI COLONIZING CEREAL GRAIN IN STORAGE STRUCTURE AND PROPERTIES GOLINSKI P CHELKOWSKI, J. (ED.). DEVELOPMENTS IN FOOD SCIENCE, VOL. 26. CEREAL GRAIN: MYCOTOXINS, FUNGI AND QUALITY IN DRYING AND STORAGE. XXII+607P. ELSEVIER SCIENCE PUBLISHERS B.V.: AMSTERDAM, NETHERLANDS; (DIST. IN THE USA AND CANADA BY ELSEVIER SCIENCE PUBLISHING CO., INC.: NEW YORK, NEW YORK, USA). ILLUS. MAPS. ISBN 0-444-88554-4.; 0 (0). 1991. 355-403.
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Image A
CT Scan 30/3/99
Showing extreme pleural thickening and 2 small cavities at apex of left lung.
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A 43 year old with smoking related emphysema was admitted to hospital with two separate episodes of haemoptysis. He had been in good health up to 1989, when he was diagnosed as having bilateral pulmonary tuberculosis. At that time a CT scan revealed a cavity in the left upper lobe (20.8cm2) with adjacent confluent infiltrates and pleural thickening. On bronchoscopic examination no abnormalities were noted and endobronchial biopsies did not reveal hyphae.
Over the next 4 years his condition deteriorated and a CT scan showed the left upper lobe cavity had increased to 40cm2. Itraconazole 400mg daily was prescribed. There was some clinical improvement on itraconazole but patient eventually deteriorated with breathlessness and with significant weight loss.
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