Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – tryptoquivaline E
Copyright: n/a
Notes:
Species: A. fumigatusSystematic name: Spiro[furan-2(5H),9′-[9H]imidazo[1,2-a]indole]-3′,5(2’H)-dione, 1′,3,4,9’a-tetrahydro-1′-hydroxy-2′-methyl-4-(4-oxo-3(4H)-quinazolinyl)-, (2S,2’S,4R,9’aS)-Molecular formulae: C22H18N4O5Molecular weight: 418.402Chemical abstracts number: 61897-87-8Selected references: Yamazaki, Mikio; Fujimoto, Haruhiro; Okuyama, Emi (Res. Inst. Chemobiodynamics, Chiba Univ., Chiba, Japan). Tetrahedron Lett., (33), 2861-4 (English) 1976.SECONDARY METABOLITES MYCOTOXINS PRODUCED BY FUNGI COLONIZING CEREAL GRAIN IN STORAGE STRUCTURE AND PROPERTIES GOLINSKI P CHELKOWSKI, J. (ED.). DEVELOPMENTS IN FOOD SCIENCE, VOL. 26. CEREAL GRAIN: MYCOTOXINS, FUNGI AND QUALITY IN DRYING AND STORAGE. XXII+607P. ELSEVIER SCIENCE PUBLISHERS B.V.: AMSTERDAM, NETHERLANDS; (DIST. IN THE USA AND CANADA BY ELSEVIER SCIENCE PUBLISHING CO., INC.: NEW YORK, NEW YORK, USA). ILLUS. MAPS. ISBN 0-444-88554-4.; 0 (0). 1991. 355-403.
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Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
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Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.
Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.
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![Asp[1]niger](https://www.aspergillus.org.uk/wp-content/uploads/2013/11/Asp1niger-150x150.gif "Asp[1]niger")
