Secondary metabolites, structure diagram: Trivial name – territrem C

Date: 26 November 2013

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Secondary metabolites, structure diagram: Trivial name – territrem C

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Species: A. terreusSystematic name: 4H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-4,4,6a,12b-tetramethyl-, (4aR-(4a-alpha,6a-beta,12a-alpha,12b-beta))-Molecular formulae: C28H32O9Molecular weight: 512.548Chemical abstracts number: 89020-33-7Selected references: Ling KH, Yang CK, Peng FT. Territrems, tremorgenic mycotoxins of Aspergillus terreus. Appl Environ Microbiol. 1979 Mar;37(3):355-7. Ling KH, Liou HH, Yang CM, Yang CK. Related Articles, Links Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem C from Aspergillus terreus. Appl Environ Microbiol. 1984 Jan;47(1):98-100. Chen JW, Ling KH. Territrems: Naturally Occurring Specific Irreversible Inhibitors of Acetylcholinesterase. J Biomed Sci. 1996 Jan;3(1):54-58.Toxicity: mouse LD50 intraperitoneal 6280ug/kg (6.28mg/kg) Applied and Environmental Microbiology. Vol. 47, Pg. 98, 1984.

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Showing 10 posts of 2574 posts found.

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  • Pseudomembranous Aspergillus tracheobronchitis

    Pt FT. Autopsy appearance of the trachea, after the adherent pseudomembrane had been removed, revealing confluent ulceration superiorly with small green plaques of Aspergillus growth on the trachea inferiorly.

    (A) Tracheal appearance at autopsy (after removal of slough) showing remarkable erythema and ulceration down to carina (Tait 1993).

  • Non invasive Aspergillus bronchitis

    This view was obtained in a lung transplant recipient at bronchoscopy. Aspergillus fumigatus was grown from bronchial lavage but invasion was not demonstrated on bronchial biopsy. Symptoms improved with itraconazole therapy and abnormal appearances had resolved within 2 weeks.

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  • Aspergillus tracheobronchitis

    Bronchoscopic view of Aspergillus tracheobronchitis. Bronchial lavage revealed hyphae in microscopy and cultures grew A.fumigatus. This man had received a lung transplant a few weeks before. Invasion of mucosa, but not cartilage, was demonstrated histologically. He responded rapidly to oral itraconazole.

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  • Laryngeal aspergillosis

    This view from indirect laryngoscopy illustrates bilateral lesions on the larynx that on biopsy were shown to be due to Aspergillus. This is a rare disease in non-immunocompromised patients.

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  • Ulcerative tracheobronchitis

    Bronchoscopic view of a deep bronchial ulcer in a lung transplant patient. Biopsies through the ulcer yielded cartilage with hyphae invading it. Fungal cultures of bronchial lavage grew Aspergillus fumigatus. He responded to oral itraconazole therapy.

    Figure 1: Ulcerative tracheobronchitis showing ulcerative plaque seen at the bronchial lining (Kramer 1991).

  • cfCTaspergillomasideview_2

  • pt NM aspergilloma with cavities following pneumonia

    Patient had life threatening pneumonia, cavity formation was later observed. He later presented with a fungal ball. The aspergilloma was removed by surgical resection of the right upper lobe.

    Image 1 08/12/2005 Pneumonia was diagnosed., Image 2 07/02/2006 Cavitation was seen., Image 3 28/08/2006 Scarring and a thin walled cavity in the upper lobe is shown. , Image 4 27/05/09 One large and several small cavities were seen the patient had recurrent chest infections., Image 5 27/05/09 CT scan confirmed the presence of several cavities and a fungal ball of 24mm in a 5cm diameter cavity. Some thickening and distortion of bronchi was noted. Pleural thickening peripheral to the cavity was seen., Image 6 27/05/09 Ct scan (2) , Image 7 28/08/09 In june 09 the patient underwent surgical resection of the right upper lobe. This subsequent X- ray was clear.

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  • ptMVhisol2

  • ptMVCT2_july_08