Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – territrem C
Copyright: n/a
Notes:
Species: A. terreusSystematic name: 4H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-4,4,6a,12b-tetramethyl-, (4aR-(4a-alpha,6a-beta,12a-alpha,12b-beta))-Molecular formulae: C28H32O9Molecular weight: 512.548Chemical abstracts number: 89020-33-7Selected references: Ling KH, Yang CK, Peng FT. Territrems, tremorgenic mycotoxins of Aspergillus terreus. Appl Environ Microbiol. 1979 Mar;37(3):355-7. Ling KH, Liou HH, Yang CM, Yang CK. Related Articles, Links Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem C from Aspergillus terreus. Appl Environ Microbiol. 1984 Jan;47(1):98-100. Chen JW, Ling KH. Territrems: Naturally Occurring Specific Irreversible Inhibitors of Acetylcholinesterase. J Biomed Sci. 1996 Jan;3(1):54-58.Toxicity: mouse LD50 intraperitoneal 6280ug/kg (6.28mg/kg) Applied and Environmental Microbiology. Vol. 47, Pg. 98, 1984.
Images library
-
Title
Legend
-
Bilateral Aspergillus osteomyelitis of the base of the skull in a non-immunocompromised woman, aged 38, following Aspergillus sinusitis. This was eventually cured with an 18 month course of voriconazole.
-
In this non-immunocompromised patient with histologically and culture proven invasive aspergillosis most of the landmarks have been surgically removed during 3 operations.
-
The maxillary sinus on the left is completely opacified with high signal, The high signal seen in the maxillary sinus on the right is of marginal significance. The sinuses and other cerebellum are normal.
-
CT scan of the sinuses shows a completely opacified sphenoid sinus in this man with AIDS (Khoo S, Denning DW. Invasive aspergillosis in patients with AIDS Clin Infect Dis 1994; 19 (suppl 1): S41-8.) He had complained of headache for about 3 months before this scan was done. In addition to sinus disease, erosion of disease through the left lateral wall of the sinus into the arterior horn of the temporal lobe, can be seen leading to a cerebral abscess. The patient was treated with itraconazole, but had undetectable serum concentrations because of prior phenytoin, and died after nine days of therapy of an MRSA bacteraemia. He was reported as an “other failure” in Denning DW, Lee JY, Hostetler JS, Pappas P, Kauffman CA, Dewsnup DH, Galgiani JN, Graybill JR, Sugar AM, Catanzaro A, Gallis H, Perfect JR, Dockery B, Dismukes WE, Stevens DA, NIAID Mycoses Study Group multicenter trial of oral itraconazole therapy of invasive aspergillosis. Am J Med 1994; 97: 135-144.
Cultures from the sinus and brain abcess grew A.fumigatus.
, 
