Secondary metabolites, structure diagram: Trivial name – territrem B

Date: 26 November 2013

Secondary metabolites, structure diagram: Trivial name – territrem B

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Species: A. terreusSystematic name: 4H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexahydro-4a,12a-dihydroxy-4,4,6a,12b-tetramethyl-9-(3,4,5-trimethoxyphenyl)-, (4aR,6aR,12aS,12bS)- 4H,11H-Naphtho(2,1-b)pyrano(3,4-e)pyran-1,11(5H)-dione, 4a,6,6a,12,12a,12b-hexaMolecular formulae: C29H34O9Molecular weight: 526.575Chemical abstracts number: 70407-20-4Selected references: Ling KH, Yang CK, Peng FT. Territrems, tremorgenic mycotoxins of Aspergillus terreus. Appl Environ Microbiol. 1979 Mar;37(3):355-7. Chen JW, Luo YL, Hwang MJ, Peng FC, Ling KH. Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. J Biol Chem. 1999 Dec 3;274(49):34916-23. Chen JW, Ling KH. Territrems: Naturally Occurring Specific Irreversible Inhibitors of Acetylcholinesterase. J Biomed Sci. 1996 Jan;3(1):54-58.Toxicity: mouse LD50 intraperitoneal 9060ug/kg (9.06mg/kg) Applied and Environmental Microbiology. Vol. 47, Pg. 98, 1984.

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Aspergillus westerdijkiae

Seven-day-old cultures on A CYA
Falcons: The following images were obtained by endoscopy of falcons with aspergillosis.A,B Thoracic airsac (T) with prominent blood vessels and a dead serratospiculum worm (W). The presence of these lung worms makes the airsac look milky. D N

Falcons: The following images were obtained by endoscopy of falcons with aspergillosis.A,B Thoracic airsac (T) with prominent blood vessels and a dead serratospiculum worm (W). The presence of these lung worms makes the airsac look milky. D Normal ovary with developing follicles.
Falcons: The following images were obtained by endoscopy of falcons with aspergillosis.B,D Aspergillus lesions (A) over a swollen liver

Falcons: The following images were obtained by endoscopy of falcons with aspergillosis.B,D Aspergillus lesions (A) over a swollen liver
Falcons: The following images were obtained by endoscopy of falcons with aspergillosis.B Cranial, middle, caudal lobes (K1,K2,K3) of the left kidney, all the lobes show slight nephromegaly.C Yellow aspergillus colony (A1), lying adjacent to the

Falcons: The following images were obtained by endoscopy of falcons with aspergillosis.B Cranial, middle, caudal lobes (K1,K2,K3) of the left kidney, all the lobes show slight nephromegaly.C Yellow aspergillus colony (A1), lying adjacent to the lung.D White aspergillus colonies (A2,A3,A4).
Falcons: The following images were obtained by endoscopy of falcons with aspergillosis.C Cranial pole of left kidney (K) -mildly inflamed.D Ovary ( F) with developing follicles.

Falcons: The following images were obtained by endoscopy of falcons with aspergillosis.C Cranial pole of left kidney (K) -mildly inflamed.D Ovary ( F) with developing follicles.
The following images were obtained by endoscopy of falcons with aspergillosis.A and B Lung Worm (S) over liver (Li) (serratospiculum seurati)C and D Aspergilloma (A) and prominent blood vessels on the caudal thoracic air sac (T).

The following images were obtained by endoscopy of falcons with aspergillosis.A and B Lung Worm (S) over liver (Li) (serratospiculum seurati)C and D Aspergilloma (A) and prominent blood vessels on the caudal thoracic air sac (T).