Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – terrein
Copyright: n/a
Notes:
Species: A. fischeri, A. lentulus, A. monodii, A. monodii, A. novofumigatus, A. olivicola, A. terreus, Emericella variecolor, Emericella venezuelensisSystematic name: 2-Cyclopenten-1-one, 4,5-dihydroxy-3-propenyl- 2-Cyclopenten-1-one, 4,5-dihydroxy-3-(1-propenyl)-Molecular formulae: C8H10O3Molecular weight: 154.163Chemical abstracts number: 582-46-7Selected references: Kiriyama, Noriki; Nitta, Keiichi; Sakaguchi, Yoshiaki; Taguchi, Yasuhisa; Yamamoto, Yuzuru (Fac. Pharm. Sci., Kanazawa Univ., Kanazawa, Japan). Chem. Pharm. Bull., 25(10), 2593-601 (English) 1977.Frisvad JC, Samson RA. Syst Appl Microbiol. 2004 Nov;27(6):672-80. Emericella venezuelensis, a new species with stellate ascospores producing sterigmatocystin and aflatoxin B1.Park SH, Kim DS, Kim WG, Ryoo IJ, Lee DH, Huh CH, Youn SW, Yoo ID, Park KC. Terrein: a new melanogenesis inhibitor and its mechanism. Cell Mol Life Sci. 2004 Nov;61(22):2878-85.
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Image A
CT Scan 30/3/99
Showing extreme pleural thickening and 2 small cavities at apex of left lung.
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A 43 year old with smoking related emphysema was admitted to hospital with two separate episodes of haemoptysis. He had been in good health up to 1989, when he was diagnosed as having bilateral pulmonary tuberculosis. At that time a CT scan revealed a cavity in the left upper lobe (20.8cm2) with adjacent confluent infiltrates and pleural thickening. On bronchoscopic examination no abnormalities were noted and endobronchial biopsies did not reveal hyphae.
Over the next 4 years his condition deteriorated and a CT scan showed the left upper lobe cavity had increased to 40cm2. Itraconazole 400mg daily was prescribed. There was some clinical improvement on itraconazole but patient eventually deteriorated with breathlessness and with significant weight loss.
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