Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – sterigmatocystin
Copyright: n/a
Notes:
Species: A. discophorus, A. flavus, A. multicolor, A. nidulans, A. olivicola, A. parasiticus, A. rambellii, A. ustus, A. versicolor, Emericella nidulans, Emericella venezuelensisSystematic name 7H-Furo[3′,2′:4,5]furo[2,3-c]xanthen-7-one, 3a,12c-dihydro-8-hydroxy-6-methoxy-, (3aR,12cS)-Molecular formulae: C18H12O6Molecular weight: 324.284Chemical abstracts number: 10048-13-2Selected references: Steyn M; Rabie C J Production of sterigmatocystin. Journal – Association of Official Analytical Chemists (1975), 58(3), 622-3. Tag, Andrew; Hicks, Julie; Garifullina, Gulnara; Ake, Charles, Jr; Phillips, T. D.; Beremand, Marian; Keller, Nancy (CORPORATE SOURCE Departments of Plant Pathology and Microbiology, Texas A and M University, College Station, TX 77843-2132, USA).Hamasaki, Takashi; Nakagomi, Takeo; Hatsuda, Yuichi; Fukuyama, Keiichi; Katsube, Yukiteru (Fac. Agric., Tottori Univ., Tottori 680, Japan). Agric. Biol. Chem., 44(5), 1149-55 (English) 1980.Frisvad JC, Skouboe P, Samson RA. Taxonomic comparison of three different groups of aflatoxin producers and a new efficient producer of aflatoxin B1, sterigmatocystin and 3-O-methylsterigmatocystin, Aspergillus rambellii sp. nov. Syst Appl Microbiol. 2005 Jul;28(5):442-53. Frisvad JC, Samson RA. Emericella venezuelensis, a new species with stellate ascospores producing sterigmatocystin and aflatoxin B1. Syst Appl Microbiol. 2004 Nov;27(6):672-80.Toxicity: Oral LD50 in albino male rat 166 mg/kg body-weight, intraperitoneal LD50 in male monkeys 32 mg/kg body-weight. It has been shown to cause liver and kidney damage including cirrhosis of the liver in primates. Hsieh DP, Atkinson DN. Bisfuranoid mycotoxins: their genotoxicity and carcinogenicity. Adv Exp Med Biol. 1991;283:525-32. Review. Produced by several Aspergillus spp, including Aspergillus nidulans, Aspergillus flavus, Aspergillus ustus and Aspergillus versicolor, the last of which is associated with the production of sterigmatocystin in cheeses stored at low temperatures for extended periods of time. It is also produced by Bipolaris sorokiniana, Monocillium nordinii, Chaetomium thielarioideum and Chaetomium udagawae.
Images library
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Title
Legend
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Necrotic lung tissue in culture
Af=Colony of Aspergillus fumigatus
B=bacterial colonies
L=lung tissue
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A photograph of part of the upper lung lobe of an immunosuppressed patient. The lung tissue shows extenive areas of necrosis due to invasive colonisation.
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A photograph of a cavity in the upper lobe of the lung of a patient with ankylosing spondylitis. Such cavitation,which may be confused with prior tuberculosis, can follow fibrosis.
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Plugs stained with Methenamine/silverActively growing mycelia of the fungus are a deep brown/black. Counterstaining shows the dense mucus of the plugs as predominantly orange.
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Sputum from an asthmatic patient showing plugs(casts). The development of plugs coincided with an increased prevalence and severity of episodes of asthma
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microscopic characters Conidiophore stipes(C)1300-2800um long:Vesicles(V)40-70um wide,clavate:Phialides(Ph) uniseriate:Conidia(Con)3.5-4.0um long,smooth walled.
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microscopic characters Conidiophore stipes(C)225-350um arising from hyphae(Hy):Vesicles(Ves)15-25um wide:Phialides(Ph)uniseriate:Conidia(Con)2.4-3.0um spherical to ovoid,roughened.
