Secondary metabolites, structure diagram: Trivial name – sphingofungin C

Date: 26 November 2013

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Secondary metabolites, structure diagram: Trivial name – sphingofungin C

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Notes:

Species: A. fumigatusSystematic name: 6-Eicosenoic acid, 5-(acetyloxy)-2-amino-3,4,14-trihydroxy-Molecular formulae: C22H41NO7Molecular weight: 431.563Chemical abstracts number: 121025-46-5Selected references: VanMiddlesworth F, Giacobbe RA, Lopez M, Garrity G, Bland JA, Bartizal K, Fromtling RA, Polishook J, Zweerink M, Edison AM, et al. J Antibiot (Tokyo). 1992 Jun;45(6):861-7. Sphingofungins A, B, C, and D; a new family of antifungal agents. I. Fermentation, isolation, and biological activity.Zweerink MM, Edison AM, Wells GB, Pinto W, Lester RL. Characterization of a novel, potent, and specific inhibitor of serine palmitoyltransferase. J Biol Chem. 1992 Dec 15;267(35):25032-8. FUMONISINS POWELL RG ; PLATTNER RD PELLETIER, S. W. (ED.). ALKALOIDS: CHEMICAL AND BIOLOGICAL PERSPECTIVES, VOL. 9. XV+286P. PERGAMON PRESS LTD: OXFORD, ENGLAND, UK; TARRYTOWN, NEW YORK, USA. ISBN 0-08-042089-3.; 0 (0). 1995. 247-278.

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Showing 10 posts of 2574 posts found.

  • Title

    Legend

  • Bronchiectasis due to ABPA

    High resolution CT scan images with reconstruction of 1mm thick slices at approximately 10mm increments. The scan shows moderately severe multi-lobar cylindrical and varicose bronchiectasis predominantly centrally and in the upper lungs. There is no mucus plugging seen.

    The features are in keeping with allergic bronchopulmonary aspergillosis

    BMJune04344, BMscanjune04347, BMjune04348

  • Allergic aspergillosis

    Allergic aspergillosis

    mayer

  • pt.SB – 6/10/98 – bronchocentric granulomatosis. CT scan showing multiple small nodules of variable size in both lung fields, apparently close to the vascular bundles.

    pt.SB – 6/10/98 – bronchocentric granulomatosis. CT scan showing multiple small nodules of variable size in both lung fields, apparently close to the vascular bundles.

    dd2

  • dup

    abpab

  • dup

    abpae

  • Bronchial oedema.Remarkably oedematous bronchial mucosa, as seen in ABPA.

    Bronchial oedema.Remarkably oedematous bronchial mucosa, as seen in ABPA.

    abpa11

  • Longstanding allergic bronchopulmonary aspergillosis

    An example of longstanding allergic bronchopulmonary aspergillosis in a patient who has been steroid dependent for over 15 years showing remarkable kyphoscoliosis and honey combing and fibrosis of both lungs.

    ABPA pt HB

  • Normal bronchial anatomy.

    Normal bronchial anatomy.

    abpa10

  • Allergic aspergillosis

    Recurrent pulmonary shadows 1. 6 Jan 1988 – chest radiograph showing right hilar enlargement, consistent with ABPA.

    Recurrent pulmonary shadows 1. 3 Feb 1989 – chest radiograph showing right upper-lobe consolidation and contraction consistent with obstruction of RUL bronchus, in ABPA.

    Clearing of pulmonary shadows 3, pt BJ. 5 April 1989 – resolution of shadows seen in February, with a course of corticosteroids.

    Recurrence of pulmonary shadows 4, pt BJ. 2 September 1989 – recurrence of pulmonary shadows with an exacerbation of ABPA.

    Central bronchiectasis, pt BJ. CT scan of thorax October 1989 showing central bronchiectasis, characteristic of ABPA (and cystic fibrosis).

    Recurrent pulmonary shadows 1, pt BJ, Recurrent pulmonary shadows 2, pt BJ. , Clearing of pulmonary shadows 3, pt BJ., Recurrence of pulmonary shadows 4, pt BJ., Central bronchiectasis, pt BJ CT scan of thorax October 1989 showing central bronchiectasis, characteristic of ABPA (and cystic fibrosis).

  • Microscopy of sputum

    A typical example of a wet mount of a sputum sample from a patient with allergic bronchopulmonary aspergillosis.

    abpa1