Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – sphingofungin C
Copyright: n/a
Notes:
Species: A. fumigatusSystematic name: 6-Eicosenoic acid, 5-(acetyloxy)-2-amino-3,4,14-trihydroxy-Molecular formulae: C22H41NO7Molecular weight: 431.563Chemical abstracts number: 121025-46-5Selected references: VanMiddlesworth F, Giacobbe RA, Lopez M, Garrity G, Bland JA, Bartizal K, Fromtling RA, Polishook J, Zweerink M, Edison AM, et al. J Antibiot (Tokyo). 1992 Jun;45(6):861-7. Sphingofungins A, B, C, and D; a new family of antifungal agents. I. Fermentation, isolation, and biological activity.Zweerink MM, Edison AM, Wells GB, Pinto W, Lester RL. Characterization of a novel, potent, and specific inhibitor of serine palmitoyltransferase. J Biol Chem. 1992 Dec 15;267(35):25032-8. FUMONISINS POWELL RG ; PLATTNER RD PELLETIER, S. W. (ED.). ALKALOIDS: CHEMICAL AND BIOLOGICAL PERSPECTIVES, VOL. 9. XV+286P. PERGAMON PRESS LTD: OXFORD, ENGLAND, UK; TARRYTOWN, NEW YORK, USA. ISBN 0-08-042089-3.; 0 (0). 1995. 247-278.
Images library
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Title
Legend
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Saggital section of the vertebral column of a dog with discospondylitis as part of disseminated aspergillosis due to A. terreus
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Discospondylitis – Radiograph of thoracolumbar vertebrae of a 2 year old, female German shepherd dog with disseminated aspergillosis demonstrating discospondylitis of T13-L1.
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Wasting and paraplegia – A 2 year old, male German shepherd dog with disseminated aspergillosis due to A. terreus. The marked loss of condition of this dog occurred within two months of initial diagnosis.
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A 2 year old, female German shephered dog with disseminated aspergillosis due to A. terreus. There is muscle wasting and paraplegia due to discospondylitis involving T13-L1.
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Draining sinus tract on left forelimb of a 4 year old, female Dalmatian with disseminated aspergillosis. There was an underlying osteomyelitis of distal humerus from which A. terreus was cultured.
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Aspergillus sinusitis in a dog. Long nosed dogs are at relatively high risk of Aspergillus sinusitis as shown in this example.
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English Pointer with nasal aspergillosis. Gram stained cytological smear of material obtained from the frontal sinus of a 7 year old English Pointer with nasal aspergillosis. This infection was caused by Aspergillus fumigatus. Magnification x 200.
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Domestic crossbred cat with disseminated aspergillosis. KOH preparation of material obtained from thoracotomy of a 3 year old domestic crossbred cat with invasive Aspergillus fumigatus infection. The cat had marked enlargement of the hilar lymph nodes that resulted in a partial tracheal obstruction. This preparation was made from portions of the hilar lymph node resected at thoracotomy. Magnification x 132.
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Rottweiler treated with indwelling plastic tubes. Photograph of a Rottweiler crossbred dog treated with indwelling plastic tubes placed surgically into the nasal cavity and frontal sinuses.
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Nasal aspergillosis in an English Pointer. Photograph of an English Pointer with nasal aspergillosis
Nasal aspergillosis in an English Pointer. Photograph of an English Pointer with nasal aspergillosis
