Secondary metabolites, structure diagram: Trivial name – sphingofungin C

Date: 26 November 2013

Secondary metabolites, structure diagram: Trivial name – sphingofungin C

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Notes:

Species: A. fumigatusSystematic name: 6-Eicosenoic acid, 5-(acetyloxy)-2-amino-3,4,14-trihydroxy-Molecular formulae: C22H41NO7Molecular weight: 431.563Chemical abstracts number: 121025-46-5Selected references: VanMiddlesworth F, Giacobbe RA, Lopez M, Garrity G, Bland JA, Bartizal K, Fromtling RA, Polishook J, Zweerink M, Edison AM, et al. J Antibiot (Tokyo). 1992 Jun;45(6):861-7. Sphingofungins A, B, C, and D; a new family of antifungal agents. I. Fermentation, isolation, and biological activity.Zweerink MM, Edison AM, Wells GB, Pinto W, Lester RL. Characterization of a novel, potent, and specific inhibitor of serine palmitoyltransferase. J Biol Chem. 1992 Dec 15;267(35):25032-8. FUMONISINS POWELL RG ; PLATTNER RD PELLETIER, S. W. (ED.). ALKALOIDS: CHEMICAL AND BIOLOGICAL PERSPECTIVES, VOL. 9. XV+286P. PERGAMON PRESS LTD: OXFORD, ENGLAND, UK; TARRYTOWN, NEW YORK, USA. ISBN 0-08-042089-3.; 0 (0). 1995. 247-278.

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Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology. Adherence areas of air sac to the celomic wall and white-yellowish nodule in the liver.

Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology. Adherence areas of air sac to the celomic wall and white-yellowish nodule in the liver.
Aspergillosis in penguins. Lesions found in fatal cases of captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis. Air sacs thickened with abundant plaque-like caseous and necrotic debris covering the wall with greyish-green fungal

Aspergillosis in penguins. Lesions found in fatal cases of captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis. Air sacs thickened with abundant plaque-like caseous and necrotic debris covering the wall with greyish-green fungal colonies on the internal surface.
Aspergillosis in penguins. Lesions found in fatal cases of captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis. Air sacs thickened with abundant plaque-like caseous and necrotic debris covering the wall with greyish-green fungal

Aspergillosis in penguins. Lesions found in fatal cases of captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis. Air sacs thickened with abundant plaque-like caseous and necrotic debris covering the wall with greyish-green fungal colonies on the internal surface.
Aspergillosis in penguins. Lesions found in fatal cases of captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis. Air sacs thickened with abundant plaque-like caseous and necrotic debris covering the wall with greyish-green fungal

Aspergillosis in penguins. Lesions found in fatal cases of captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis. Air sacs thickened with abundant plaque-like caseous and necrotic debris covering the wall with greyish-green fungal colonies on the internal surface.
Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis.Lung parenchyma with congestion, hemorrhagic and necrotic areas and with multiple white-yellowish granulomatous nodules, ranging fr

Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis.Lung parenchyma with congestion, hemorrhagic and necrotic areas and with multiple white-yellowish granulomatous nodules, ranging from 0.1-1.0 cm in diameter
Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis. Lung parenchyma with congestion, hemorrhagic and necrotic areas and with multiple white-yellowish granulomatous nodules, ranging fro

Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis. Lung parenchyma with congestion, hemorrhagic and necrotic areas and with multiple white-yellowish granulomatous nodules, ranging from 0.1-1.0 cm in diameter
Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis.

Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis.
Image shows an avian airsac

Image shows an avian airsac
Aspergillosis in an air sac of a hen

Aspergillosis in an air sac of a hen