Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – secalonic acid D
Copyright: n/a
Notes:
Species: A. aculeatus, A. ochraceus, A. uvarumSystematic name: [7,7′-Bi-4aH-xanthene]-4a,4’a-dicarboxylic acid, 2,2′,3,3′,4,4′,9,9′-octahydro-1,1′,4,4′,8,8′-hexahydroxy-3,3′-dimethyl-9,9′-dioxo-, dimethyl ester, (3S,3’S,4R,4’R,4aR,4’aR)-Molecular formulae: C32 H30 O14Molecular weight: 638.581Chemical abstracts number: 35287-69-5Selected references: Andersen, Raymond; Buechi, George; Kobbe, Brunhilde; Demain, Arnold L. (Dep. Chem., Massachusetts Inst. Technol., Cambridge, Mass., USA). J. Org. Chem., 42(2), 352-3 (English) 1977.Kurobane I, Vining LC, McInnes AG. J Antibiot (Tokyo). 1979 Dec;32(12):1256-66. Biosynthetic relationships among the secalonic acids. Isolation of emodin, endocrocin and secalonic acids from Pyrenochaeta terrestris and Aspergillus aculeatus.Toxicity: mouse LD50 intraperitoneal 26500ug/kg (26.5mg/kg) EFFECTS: VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION LUNGS, THORAX, OR RESPIRATION: CHANGES IN PULMONARY VASCULAR RESISTANCE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Applied and Environmental Microbiology. Vol. 39, Pg. 285, 1980. mouse LD50 intravenous 25mg/kg (25mg/kg) EFFECTS: BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: FOOD INTAKE (ANIMAL) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Journal of Toxicology and Environmental Health. Vol. 5, Pg. 1159, 1979.mouse LDLo oral 30mg/kg (30mg/kg) EFFECTS: SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION LIVER: HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology and Applied Pharmacology. Vol. 48, Pg. A14, 1979. rat LD50 oral 22mg/kg (22mg/kg) EFFECTS: SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION LIVER: HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology and Applied Pharmacology. Vol. 48, Pg.
Images library
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Saggital section of the vertebral column of a dog with discospondylitis as part of disseminated aspergillosis due to A. terreus
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Discospondylitis – Radiograph of thoracolumbar vertebrae of a 2 year old, female German shepherd dog with disseminated aspergillosis demonstrating discospondylitis of T13-L1.
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Wasting and paraplegia – A 2 year old, male German shepherd dog with disseminated aspergillosis due to A. terreus. The marked loss of condition of this dog occurred within two months of initial diagnosis.
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A 2 year old, female German shephered dog with disseminated aspergillosis due to A. terreus. There is muscle wasting and paraplegia due to discospondylitis involving T13-L1.
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Draining sinus tract on left forelimb of a 4 year old, female Dalmatian with disseminated aspergillosis. There was an underlying osteomyelitis of distal humerus from which A. terreus was cultured.
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Aspergillus sinusitis in a dog. Long nosed dogs are at relatively high risk of Aspergillus sinusitis as shown in this example.
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English Pointer with nasal aspergillosis. Gram stained cytological smear of material obtained from the frontal sinus of a 7 year old English Pointer with nasal aspergillosis. This infection was caused by Aspergillus fumigatus. Magnification x 200.
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Domestic crossbred cat with disseminated aspergillosis. KOH preparation of material obtained from thoracotomy of a 3 year old domestic crossbred cat with invasive Aspergillus fumigatus infection. The cat had marked enlargement of the hilar lymph nodes that resulted in a partial tracheal obstruction. This preparation was made from portions of the hilar lymph node resected at thoracotomy. Magnification x 132.
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Rottweiler treated with indwelling plastic tubes. Photograph of a Rottweiler crossbred dog treated with indwelling plastic tubes placed surgically into the nasal cavity and frontal sinuses.
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Nasal aspergillosis in an English Pointer. Photograph of an English Pointer with nasal aspergillosis
Nasal aspergillosis in an English Pointer. Photograph of an English Pointer with nasal aspergillosis
