Secondary metabolites, structure diagram: Trivial name - paraherquamide

Date: 26 November 2013

Secondary metabolites, structure diagram: Trivial name – paraherquamide

Notes:

Species: A. silvaticusSystematic name: Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,7′(8’H)-[5H,6H-5a,9a](iminomethano)[1H]cyclopent[f]indolizine]-9,10′(10H)-dione, 2′,3′,8’a,9′-tetrahydro-1′-hydroxy-1′,4,4,8′,8′,11′-hexamethyl-, (1’R,5’aS,7’R,8’aS,9’aR)-Molecular formulae: C28H35N3O5Molecular weight: 493Chemical abstracts number: 77392-58-6Selected references: Yamazaki, M.; Fujimoto, H.; Okuyama, E.; Ohta, Y. (Res. Inst. Chemobiodyn., Chiba Univ., Chiba 280, Japan). Maikotokishin (Tokyo), 10, 27-8 (Japanese) 1980.

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Aspergillus fumigatus Fresen

Aspergillus fumigatus Fresen
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920

Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
Aspergillus cretensis

Conidia
Aspergillus cretensis

Seven-day-old cultures on CYA
Aspergillus cretensis

Conidiophores
Aspergillus clavatus

A colour enhanced image.
Cerebral aspergillosis – CT scans, CLL patient DS.

Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.

Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.

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