Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Orlandin
Copyright: n/a
Notes:
Species: A. nigerSystematic name: [8,8′-Bi-2H-1-benzopyran]-2,2′-dione, 7,7′-dihydroxy-4,4′-dimethoxy-5,5′-dimethyl-Molecular formulae: C22H18O8Molecular weight: 410Chemical abstracts number: 69975-77-5Selected references: Orlandin: a nontoxic fungal metabolite with plant growth inhibiting properties. Cutler, Horace G.; Crumley, Farrist G.; Cox, Richard H.; Hernandez, Oscar; Cole, Richard J.; Dorner, Joe W. Georgia Coastal Plain Exp. Stn., Sci. Educ. Adm., Tifton, GA, USA. Journal of Agricultural and Food Chemistry (1979), 27(3), 592-5.
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Drug rashes: Drug interactions between steroids and anti-fungal drugs – (ecchymosis)
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Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.
Courtesy of Dr D Denning, Wythenshawe Hospital, Manchester.(© Fungal Research Trust),
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Micrographs of A. niger conidia & conidial heads provided by Amaliya Stepanova, Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. terreus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Patients has history of ABPA complicating long standing asthma. His total IgE has fluctuated between 2,200 and 4,600 KU/L, his Aspergillus IgE between 36.3 and 65.4 kAU/L and Aspergillus IgG from 87-154 mg/L. He has been taking long term itraconazole.
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