Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Orlandin
Copyright: n/a
Notes:
Species: A. nigerSystematic name: [8,8′-Bi-2H-1-benzopyran]-2,2′-dione, 7,7′-dihydroxy-4,4′-dimethoxy-5,5′-dimethyl-Molecular formulae: C22H18O8Molecular weight: 410Chemical abstracts number: 69975-77-5Selected references: Orlandin: a nontoxic fungal metabolite with plant growth inhibiting properties. Cutler, Horace G.; Crumley, Farrist G.; Cox, Richard H.; Hernandez, Oscar; Cole, Richard J.; Dorner, Joe W. Georgia Coastal Plain Exp. Stn., Sci. Educ. Adm., Tifton, GA, USA. Journal of Agricultural and Food Chemistry (1979), 27(3), 592-5.
Images library
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High resolution CT scan images with reconstruction of 1mm thick slices at approximately 10mm increments. The scan shows moderately severe multi-lobar cylindrical and varicose bronchiectasis predominantly centrally and in the upper lungs. There is no mucus plugging seen.
The features are in keeping with allergic bronchopulmonary aspergillosis
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pt.SB – 6/10/98 – bronchocentric granulomatosis. CT scan showing multiple small nodules of variable size in both lung fields, apparently close to the vascular bundles.
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Bronchial oedema.Remarkably oedematous bronchial mucosa, as seen in ABPA.
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An example of longstanding allergic bronchopulmonary aspergillosis in a patient who has been steroid dependent for over 15 years showing remarkable kyphoscoliosis and honey combing and fibrosis of both lungs.
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Recurrent pulmonary shadows 1. 6 Jan 1988 – chest radiograph showing right hilar enlargement, consistent with ABPA.
Recurrent pulmonary shadows 1. 3 Feb 1989 – chest radiograph showing right upper-lobe consolidation and contraction consistent with obstruction of RUL bronchus, in ABPA.
Clearing of pulmonary shadows 3, pt BJ. 5 April 1989 – resolution of shadows seen in February, with a course of corticosteroids.
Recurrence of pulmonary shadows 4, pt BJ. 2 September 1989 – recurrence of pulmonary shadows with an exacerbation of ABPA.
Central bronchiectasis, pt BJ. CT scan of thorax October 1989 showing central bronchiectasis, characteristic of ABPA (and cystic fibrosis).
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A typical example of a wet mount of a sputum sample from a patient with allergic bronchopulmonary aspergillosis.
