Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Mellein/ Ochracin
Copyright: n/a
Notes:
Species: A. melleusSystematic name: 1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-methyl-, (3R)-Molecular formulae: C10H10O3Molecular weight: 178Chemical abstracts number: 480-33-1Selected references: Holker, John S. E.; Simpson, Thomas J. (Dep. Org. Chem., Univ. Liverpool, Liverpool L69 3BX, Engl.). J. Chem. Soc., Perkin Trans. 1, (5), 1397-400 (English) 1981.
Images library
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The chest x-ray shows a patient who had a left lung transplanted in May 2003 for cryptogenic fibrosing alveolitis, which was diagnosed post-transplant as sarcoidosis.
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Gross pathology demonstrating the great pleural thickness and two cavities (upper lobe and superior segment of lower lobe) with fragments of fungal mass.
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Histopathological appearance of a fungus ball. Note a conidial head resulting from fungal exposure to the air.
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Histopathological appearance of a fungus ball caused by Scedosporium apiospermum. The presence of anneloconidia differentiates it from Aspergillus.
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Chronic necrotising aspergillosis. Hyaline hyphal and calcium oxalate crystals obtained by needle aspirate biopsy from a diabetic patient with chronic necrotizing aspergillosis caused by Aspergillus niger (Papanicolaou, x 100).
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Aspergillus niger fungus ball and acute oxalosis. Higher magnification of adjacent replicate section.
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Oxalate crystals within renal tubuli (H&E, phase contrast, x 100). This patient developed acute oxalosis.
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Lung surface. Fungus ball, severe parenchymal fibrosis and pleural thickening.
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