Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – malformins
Copyright: n/a
Notes:
Species: A. nigerSystematic name: Cyclo(D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-leucyl), cyclic (1®2)-disulfideMalformin AMolecular formulae: C23H39N5O5S2Molecular weight: 529.718Chemical abstracts number: 3022-92-2Selected references: Kim KW, Sugawara F, Yoshida S, Murofushi N, Takahashi N, Curtis RW. Structure of malformin B, a phytotoxic metabolite produced by Aspergillus niger. Biosci Biotechnol Biochem. 1993 May;57(5):787-91.Toxicity: mouse LD50 intraperitoneal 3100ug/kg (3.1mg/kg) EFFECTS: GASTROINTESTINAL: OTHER CHANGES. LIVER: OTHER CHANGES. KIDNEY, URETER, AND BLADDER: OTHER CHANGES Agricultural and Biological Chemistry. Vol. 39, Pg. 1325, 1975.
Images library
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Mitochondria organisation: GFP fluorescence micrographs showing mitochondrial organisation in an A.nidulans strain with GFP mitochondria, grown at 25°C in minimal media.
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Colony morphology of A.nidulans SRF200 after two days at 37°C
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Aspergillus nidulans. Cell nuclei-Ds red. DsRed fluorescence micrographs showing nuclear distribution in an A.nidulans germling with dsRed stained nuclei
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Cell Biology – Aspergillus nidulans. Cell nuclei-GFP. Nuclear distribution: GFP fluorescence mirographs showing fungal cell morphology and nuclear distribution in A.nidulans. GFP stained nuclei,grown at 25°C in minimal media O/N
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High resolution CT scan of chest.CT scan demonstrating remarkable bronchial wall thickening of the right main bronchus and main branches, in context of longstanding ABPA
