Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – malformins
Copyright: n/a
Notes:
Species: A. nigerSystematic name: Cyclo(D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-leucyl), cyclic (1®2)-disulfideMalformin AMolecular formulae: C23H39N5O5S2Molecular weight: 529.718Chemical abstracts number: 3022-92-2Selected references: Kim KW, Sugawara F, Yoshida S, Murofushi N, Takahashi N, Curtis RW. Structure of malformin B, a phytotoxic metabolite produced by Aspergillus niger. Biosci Biotechnol Biochem. 1993 May;57(5):787-91.Toxicity: mouse LD50 intraperitoneal 3100ug/kg (3.1mg/kg) EFFECTS: GASTROINTESTINAL: OTHER CHANGES. LIVER: OTHER CHANGES. KIDNEY, URETER, AND BLADDER: OTHER CHANGES Agricultural and Biological Chemistry. Vol. 39, Pg. 1325, 1975.
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Scanning electron microscope image of A. lentulus conidiophore Magnification 2000X
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Aspergillus lentulus. Differential interphase contrast microscopy microscopy images of conidial heads of A.lentulus . Magnification 60X.
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Allergic Aspergillus Sinusitis -Patient AM. C – Extensive involvement of both maxillary sinuses, with soft tissue swelling. Swelling of both turbinates also visible.
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Allergic Aspergillus Sinusitis -Patient AM. D – Marked involvement of ehmoidal air cells on the right , together with the inferior aspect of the sphenoid sinus. The left side is almost clear of disease.
