Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – malformins
Copyright: n/a
Notes:
Species: A. nigerSystematic name: Cyclo(D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-leucyl), cyclic (1®2)-disulfideMalformin AMolecular formulae: C23H39N5O5S2Molecular weight: 529.718Chemical abstracts number: 3022-92-2Selected references: Kim KW, Sugawara F, Yoshida S, Murofushi N, Takahashi N, Curtis RW. Structure of malformin B, a phytotoxic metabolite produced by Aspergillus niger. Biosci Biotechnol Biochem. 1993 May;57(5):787-91.Toxicity: mouse LD50 intraperitoneal 3100ug/kg (3.1mg/kg) EFFECTS: GASTROINTESTINAL: OTHER CHANGES. LIVER: OTHER CHANGES. KIDNEY, URETER, AND BLADDER: OTHER CHANGES Agricultural and Biological Chemistry. Vol. 39, Pg. 1325, 1975.
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Bronchoscopic manifestations of Aspergillus tracheobronchitis. (a) Type I. Inflammatory infiltration, mucosa hyperaemia and plaques of pseudomembrane formation in the lumen without obvious airway occlusion. (b) Type II. Deep ulceration of the bronchial wall. (c) Type III. Significant airway occlusion by thick mucous plugs full of Aspergillus without definite deeper tissue invasion. (d) Type IV. Extensive tissue necrosis and pseudomembrane formation in the lumen with airway structures and severe airway occlusion (Wu 2010).
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High resolution CT showing centrilobular nodular opacities and branching linear opacities (tree-in-bud appearance) (Al-Alawi 2007).
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Chest X-ray showing poorly defined bilateral nodular opacities (Al-Alawi 2007).
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Gross pathologic specimen from autopsy shows the bronchial lumen covered by multiple whitish endobronchial nodules (arrows) (Franquet 2002).
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Invasive tracheobronchitis showing numerous nodules seen during bronchoscopy (Ronan D’Driscoll).
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Pseudomembranous seen overlying the bronchial mucosa (Tasci 2006).
