Secondary metabolites, structure diagram: Trivial name - Itaconic acid

Date: 26 November 2013

Secondary metabolites, structure diagram: Trivial name – Itaconic acid

Notes:

Species: A. terreusSystematic name: 2-methylidenebutanedioic acidMolecular formulae: C5H6O4Molecular weight: 130.099Chemical abstracts number: 811Selected references: LARSEN H, EIMHJELLEN KE. The mechanism of itaconic acid formation by Aspergillus terreus. 1. The effect of acidity. Biochem J. 1955 May;60(1):135-9. EIMHJELLEN KE, LARSEN H. The mechanism of itaconic acid formation by Aspergillus terreus. 2. The effect of substrates and inhibitors. Biochem J. 1955 May;60(1):139-47.

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Aspergillus fumigatus Fresen

Aspergillus fumigatus Fresen
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920

Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
Aspergillus cretensis

Conidia
Aspergillus cretensis

Seven-day-old cultures on CYA
Aspergillus cretensis

Conidiophores
Aspergillus clavatus

A colour enhanced image.
Cerebral aspergillosis – CT scans, CLL patient DS.

Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.

Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.

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