Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Itaconic acid
Copyright: n/a
Notes:
Species: A. terreusSystematic name: 2-methylidenebutanedioic acidMolecular formulae: C5H6O4Molecular weight: 130.099Chemical abstracts number: 811Selected references: LARSEN H, EIMHJELLEN KE. The mechanism of itaconic acid formation by Aspergillus terreus. 1. The effect of acidity. Biochem J. 1955 May;60(1):135-9. EIMHJELLEN KE, LARSEN H. The mechanism of itaconic acid formation by Aspergillus terreus. 2. The effect of substrates and inhibitors. Biochem J. 1955 May;60(1):139-47.
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Mr RM is 80 and an ex-coal miner.He developed pneumoconiosis from exposure to coal dust. He also developed rheumatoid arthritis and the combination of this disease and pneumoconiosis is called Caplan’s syndrome.
His chest Xray in early 2015 shows extensive bilateral pulmonary shadowing with solid looking nodules superimposed on abnormal lung fields, contraction of his left lung with an elevated diaphragm and a large left upper lobe aspergilloma, displaying a classic air crescent. His CT scan from mid 2014 demonstrates a large aspergilloma in a cavity on the left, with marked pleural thickening around it, which is partially ‘calcified’ towards its base. Inferiorly on other images,remarkable pleural thickening and fibrotic irregular and spiculated nodules are seen, most partially calcified.
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