Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Isosulochrin dehydrate
Copyright: n/a
Notes:
Species: A. wentiiSystematic name: 9H-Xanthene-1-carboxylic acid, 8-hydroxy-3-methoxy-6-methyl-9-oxo-, methyl esterMolecular formulae; C17H14O6Molecular weight: 314Chemical abstracts number: 77282-74-7Selected references: Secondary mold metabolites. IX. Structure of a new bianthrone and of three new secoanthraquinones from Aspergillus wentii Wehmer. Assante, Gemma; Camarda, Lorenzo; Nasini, Gianluca. Ist. Patol. Veg., Univ. Milano, Milan, Italy. Gazzetta Chimica Italiana (1980), 110(11-12), 629-31. CODEN: GCITA9 ISSN: 0016-5603. Journal written in English. CAN 94:153102 AN 1981:153102 CA
Images library
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Yamik catheter for rinsing nasal and paranasal cavities. Image B
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Yamik catheter for rinsing nasal and paranasal cavities. Image E
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Patient with allergic fungal sinusitis. Eosinophilic mucin with A. flavus in the nasal cavity. Irregular crust of 2.5 cm from a patient diagnosed as allergic fungal sinusitis.
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This patient was diagnosed with Myelodyspasia/ Acute Myeloid Leukaemia in January 05. When he received intensive chemotherapy. Had previous history of chronic sinusitis, but after chemotherapy he developed significant maxillary sinusitis. He was treated with Caspofungin with good response, and subsequently with voriconazole. Patient has further CT scans in August 05 with myelodysplasia in remission.
A biopsy of ethmoid sinus in May showed a chronic inflammmatory process with bony invasion by fungal hyphae. The patient was in remission from myelodysplasia and was not undergoing treatment for this at the time of the scans.
In Aug 05 scans show the right maxillary sinus is now opacified. Destruction of superior medial wall of right maxillary sinus. Superiorly there was bone destruction with communication with the lower right ethmoid air cells. Lateral wall of right maxillary sinus remains thick walled with irregular periosteal thickening. No significant abnormality is seen within the nasal cavity or left paranasal sinuses. The biopsy of the ethmoid sinus revealed hyphae consistent with aspergillus. Since the patient was on voriconazole at this time this may indicate resistance. The case is ongoing with further surgery for debridement of right nasal side imminent. The patient is currently in remission.
Feb 06 D Denning
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This 33 year old woman with severe asthma since childhood and recent nasal obstruction, who did not fulfil the criteria for ABPA, had evidence of skin test sensitisation to Aspergillus. Itraconazole therapy orally improved her pulmonary symptoms and allowed a substantial reduction in the need for oral steroids and inhaled steroids. Nasal polyposis improved slightly, but she still required polypectomy and nasal steroids.
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Further details
Image A. The bone appears normal, but the features are most consistent with infection, less so with a pseudotumour. Bone windows not shown. Biopsy demonstrated hyphal invasion and cultures grew A. fumigatus.
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