Secondary metabolites, structure diagram: Trivial name – Gregatin

Date: 26 November 2013

Secondary metabolites, structure diagram: Trivial name – Gregatin

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Notes:

Species: A. panamensisSystematic name: 3(2H)-Furanone, 2-(1,3-hexadienyl)-4-(3-hydroxy-1-oxobutyl)-5-methoxy-2-methyl- (9CI)Molecular formulae: C16H22O5Molecular weight: 166Chemical abstracts number: 65831-50-7Selected references: Anke, H.; Schwab, H.; Achenbach, H. Metabolic products of microorganisms. 197. Investigations on metabolites of microorganisms. 23. Tetronic acid derivatives from Aspergillus panamensis. Production, isolation, characterization and biological activity


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  • Culture plates on different media. A Colonies on CZ at 24oC, B on CYA at 20oC C on SAB at 37oC, D on CYA at 24oC

    persiicolonies

  • D Sinusitis radiology with fluid level

  • C Bronchiectasis white cell scan (right) – left shows a normal scan for comparison

  • B Bronchogram showing bronchiectasis

  • A Bronchogram showing saccular bronchiectasis

  • Mucous containing Charcot-Leyden crystals, stained with H & EA 57 year old woman presented with breathlessness. She had a history of mild asthma for which she occasionally took salbutamol inhaler puffs. The patient underwent a pneumonectomy because of the severity of her disease process, and uncertainty about the diagnosis, prior to serology results being obtained.Serology showed an IgE of 2600, with a strongly positive Aspergillus RAST test and weakly positive Aspergillus precipitins. Material re