Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – fumigaclavine C
Copyright: n/a
Notes:
Species: A. fumigatusSystematic name: Ergolin-9-ol, 2-(1,1-dimethyl-2-propenyl)-6,8-dimethyl-, acetate (ester), (8-beta,9-beta)-Molecular formulae: C23H30N2O2Molecular weight: 366.497Chemical abstracts number: 62867-47-4Selected references: COLE RJ ; KIRKSEY JW ; DORNER JW ; WILSON DM ; JOHNSON J C JR ; JOHNSON AN ; BEDELL DM ; SPRINGER JP ; CHEXAL KK ; ET AL. J AGRIC FOOD CHEM; 25 (4). 1977 826-830. Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage.Toxicity: The clavine alkaloids, fumigaclavine A, a new alkaloid designated fumigaclavine C and several tremorgens belonging to the fumitremorgen group were produced by A. fumigatus strains isolated from molded silage. The LD50 of fumigaclavine C was about 150 mg/kg oral dose in day-old cockerels. Calves dosed with crude extracts of A. fumigatus cultures experienced severe diarrhea, irritability and loss of appetite. Postmortem examination showed serous enteritis and evidence of interstitial changes in the lungs; abnormal changes were not found in other tissues.
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4 Total obstruction of the sinuses due to inflamed mucosa. (Patient 04)
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1 Axial computed tomography (CT) scans of the frontal sinus.
A: due to the long lasting pressure of mucus, the bone of the anterior wall of frontal sinus is thinned out and elevated anteriorly, forming a bulge. B: same situation as depicted in fig A: the posterior bony wall of frontal sinus is thinned out and extremely elevated posteriorly towards the frontal lobe of the brain. As depicted on the scan, a thin bony layer covering the dura could be recognized intraoperatively
