Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – fumigaclavine C
Copyright: n/a
Notes:
Species: A. fumigatusSystematic name: Ergolin-9-ol, 2-(1,1-dimethyl-2-propenyl)-6,8-dimethyl-, acetate (ester), (8-beta,9-beta)-Molecular formulae: C23H30N2O2Molecular weight: 366.497Chemical abstracts number: 62867-47-4Selected references: COLE RJ ; KIRKSEY JW ; DORNER JW ; WILSON DM ; JOHNSON J C JR ; JOHNSON AN ; BEDELL DM ; SPRINGER JP ; CHEXAL KK ; ET AL. J AGRIC FOOD CHEM; 25 (4). 1977 826-830. Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage.Toxicity: The clavine alkaloids, fumigaclavine A, a new alkaloid designated fumigaclavine C and several tremorgens belonging to the fumitremorgen group were produced by A. fumigatus strains isolated from molded silage. The LD50 of fumigaclavine C was about 150 mg/kg oral dose in day-old cockerels. Calves dosed with crude extracts of A. fumigatus cultures experienced severe diarrhea, irritability and loss of appetite. Postmortem examination showed serous enteritis and evidence of interstitial changes in the lungs; abnormal changes were not found in other tissues.
Images library
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Scanning electron micrograph of Aspergillus ochraceopetaliformis conidial heads
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Image D & E. A case of onychomycosis associated with Aspergillus ochraceopetaliformis as described in Nail infection by Aspergillus ochraceopetaliformis. Med Mycol. 2009 Mar 9:1-5, 2009, Brasch J, Varga J, Jensen JM, Egberts F & Tintelnot K
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Image 5. Oral itraconazole pulse therapy was given to the patient (200 mg twice daily for 1 week, with 3 weeks off between successive pulses, for four pulses) and treatment was successful.
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This patient was 28 yr old with adult lymphocytic leukaemia. She received induction chemotherapy and this infection developed 2 days after recovering from neutropenia.
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Close-up image of the lesion on the left thigh showing a mat of hyphae over the wound.
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Eosinophilic mucin with A. flavus in the nasal cavity. Irregular crust of 2.5 cm from a patient diagnosed as allergic fungal sinusitis. Patient with allergic fungal sinusitis
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GMS stain of eosinophilic mucin reveals a darkly stained dichotomously branched A. flavus hyphae within cellular background. Patient with allergic fungal sinusitis
