Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – echinuline
Copyright: n/a
Notes:
Species: A. amstelodami, A. amstelodami, A. chevalieri, A. herbariorum ser. minor, Eurotium chevalieriSystematic name: 2,5-Piperazinedione, 3-[[2-(1,1-dimethyl-2-propenyl)-5,7-bis(3-methyl-2-butenyl)-1H-indol-3-yl]methyl]-6-methyl-, (3S,6S)- (9CI)2,5-Piperazinedione, 3-((2-(1,1-dimethyl-2-propenyl)-5,7-bis(3-methyl-2-butenyl)-1H-indol-3-yl)methyl)-6-methyl-, (3S,6Molecular formulae: C29H39N3O2Molecular weight: 461.639Chemical abstracts number: 1859-87-6Selected references: Ali M, Mohammed N, Alnaqeeb MA, Hassan RA, Ahmad HS. Toxicol Lett. 1989 Sep;48(3):235-41. Toxicity of echinulin from Aspergillus chevalieri in rabbits. Vesonder RF, Lambert R, Wicklow DT, Biehl ML. Appl Environ Microbiol. 1988 Mar;54(3):830-1. Eurotium spp. and echinulin in feed refused by swine.Biochemistry 11(11):2154;1972
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Drug rashes: Drug interactions between steroids and anti-fungal drugs – (ecchymosis)
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Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.
Courtesy of Dr D Denning, Wythenshawe Hospital, Manchester.(© Fungal Research Trust),
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Micrographs of A. niger conidia & conidial heads provided by Amaliya Stepanova, Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. terreus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Patients has history of ABPA complicating long standing asthma. His total IgE has fluctuated between 2,200 and 4,600 KU/L, his Aspergillus IgE between 36.3 and 65.4 kAU/L and Aspergillus IgG from 87-154 mg/L. He has been taking long term itraconazole.
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