Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Dihydrosterigmatocystin
Copyright: n/a
Notes:
Species: A. versicolorSystematic name: 7H-Furo[3′,2′:4,5]furo[2,3-c]xanthen-7-one, 1,2,3a,12c-tetrahydro-8-hydroxy-6-methoxy-, (3aR-cis)-Molecular formulae: C18H14O6Molecular weight: 326Chemical abstracts number: 6795-16-0Selected references: Davies, J. E.; Roberts, John C.; Wallwork, S. C. Sterigmatocystin, a metabolic product of Aspergillus versicolor. Chemistry & Industry (London, United Kingdom) (1956), 178. CODEN: CHINAG ISSN:0009-3068. CAN 50:89278 AN 1956:89278 CAPLUS
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The chest x-ray shows a patient who had a left lung transplanted in May 2003 for cryptogenic fibrosing alveolitis, which was diagnosed post-transplant as sarcoidosis.
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Gross pathology demonstrating the great pleural thickness and two cavities (upper lobe and superior segment of lower lobe) with fragments of fungal mass.
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Histopathological appearance of a fungus ball. Note a conidial head resulting from fungal exposure to the air.
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Histopathological appearance of a fungus ball caused by Scedosporium apiospermum. The presence of anneloconidia differentiates it from Aspergillus.
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Chronic necrotising aspergillosis. Hyaline hyphal and calcium oxalate crystals obtained by needle aspirate biopsy from a diabetic patient with chronic necrotizing aspergillosis caused by Aspergillus niger (Papanicolaou, x 100).
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Aspergillus niger fungus ball and acute oxalosis. Higher magnification of adjacent replicate section.
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Oxalate crystals within renal tubuli (H&E, phase contrast, x 100). This patient developed acute oxalosis.
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Lung surface. Fungus ball, severe parenchymal fibrosis and pleural thickening.