Secondary metabolites, structure diagram: Trivial name - Dihydrosterigmatocystin

Date: 26 November 2013

Secondary metabolites, structure diagram: Trivial name – Dihydrosterigmatocystin

Notes:

Species: A. versicolorSystematic name: 7H-Furo[3′,2′:4,5]furo[2,3-c]xanthen-7-one, 1,2,3a,12c-tetrahydro-8-hydroxy-6-methoxy-, (3aR-cis)-Molecular formulae: C18H14O6Molecular weight: 326Chemical abstracts number: 6795-16-0Selected references: Davies, J. E.; Roberts, John C.; Wallwork, S. C. Sterigmatocystin, a metabolic product of Aspergillus versicolor. Chemistry & Industry (London, United Kingdom) (1956), 178. CODEN: CHINAG ISSN:0009-3068. CAN 50:89278 AN 1956:89278 CAPLUS

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Aspergillus fumigatus Fresen

Aspergillus fumigatus Fresen
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920

Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
Aspergillus cretensis

Conidia
Aspergillus cretensis

Seven-day-old cultures on CYA
Aspergillus cretensis

Conidiophores
Aspergillus clavatus

A colour enhanced image.
Cerebral aspergillosis – CT scans, CLL patient DS.

Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.

Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.

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