Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Dehydroaustin
Copyright: n/a
Notes:
Species: A. niger, A. stellatus, A. ustus, Emericella dentataSystematic name: Spiro[1H,4H,8H-3a,7a-epoxy-6,11b-methano-3H-furo[3,4-e][3]benzoxocin-9(10H),3′(6’H)-[2H]pyran]-1,4,6′-trione, 7-(acetyloxy)-6,7,11,11a-tetrahydro-2′,2′,3,6,11a-pentamethyl-8,12-bis(methylene)-, (3R,3’R,3aR,6S,7R,7aR,11aR,11bS)-Molecular formulae: C27H30O9Molecular weight: 498Chemical abstracts number: 82893-35-4Selected references: Maebayashi, Yukio; Okuyama, Emi; Yamazaki, Mikio; Katsube, Yukiteru. Structure of ED-1 isolated from Emericella dentata. Chemical & Pharmaceutical Bulletin (1982), 30(5), 1911-12. Simpson, Thomas J.; Stenzel, Desmond J.; Bartlett, Alan J.; O’Brien, Eugene; Holker, John S. E. Studies on fungal metabolites. Part 3. Carbon-13 NMR spectral and structural studies on austin and new related meroterpenoids from Aspergillus ustus, Aspergillus variecolor, and Penicillium diversum. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1982), (11), 2687-92.
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Patient with chronic productive cough, chest pain and ABPA, unable to take itraconazole or nebulised amphotericin B. Smokes at least 40 roll up cigarettes a day.
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Laryngeal aspergillosis, probably related to inhaled corticosteroids.
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VL-2397 (formerly known as ASP2397) is a novel antifungal drug initially developed by our partner, Astellas Pharma. This drug was isolated from a leaf litter fungus Acremonium species collected in a Malaysian national park. Astellas presented two posters at the 2014 ICAAC meeting which described the in vitro and the in vivo antifungal activities of this drug. The differentiating attributes from the preclinical data of VL-2397 include:
- A novel mechanism of action, with a potential to be complementary or synergistic with the existing classes of antifungals.
- Rapid fungal cell kill activity demonstrated in preclinical models, which was faster than marketed antifungals.
- Activity against azole-resistant fungal species.
- Low propensity for P450 drug-drug interactions.
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SCY-078, new orally available beta-1,3-d-glucan synthase inhibitor, Formely MK-3118.
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Pt DSM Community acquired primary Aspergillus pneumonia. Two x-rays taken on 02/02/2010 then 05/03/2010
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