Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Austamide
Copyright: n/a
Notes:
Species: A. ustusSystematic name: Spiro[2H-indole-2,7′ (8’H)-[3H,5H]pyrrolo[1′, 2′:4,5]pyrazino[1,2-a]azepine]-3,5′,12′(1H,2’H)-trione, 5’a, 6′-dihydro-8′,8′-dimethyl-, (5’aS-trans)-Molecular formulae: C21H21N3O3Molecular weight: 363.41Chemical abstracts number: 34427-31-1
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Drug rashes: Drug interactions between steroids and anti-fungal drugs – (ecchymosis)
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Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.
Courtesy of Dr D Denning, Wythenshawe Hospital, Manchester.(© Fungal Research Trust),
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Micrographs of A. niger conidia & conidial heads provided by Amaliya Stepanova, Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. terreus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Patients has history of ABPA complicating long standing asthma. His total IgE has fluctuated between 2,200 and 4,600 KU/L, his Aspergillus IgE between 36.3 and 65.4 kAU/L and Aspergillus IgG from 87-154 mg/L. He has been taking long term itraconazole.
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