Secondary metabolites, structure diagram: Trivial name - Asterriquinone B1

Date: 26 November 2013

Secondary metabolites, structure diagram: Trivial name – Asterriquinone B1

Notes:

Species: A. terreusSystematic name: 2,5-Cyclohexadiene-1,4-dione, 2-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dimethoxy-5-[7-(3-methyl-2-butenyl)-1H-indol-3-yl]-Molecular formulae: C34H34N2O4Molecular weight: 534Chemical abstracts number: 78708-35-7Selected references: Arai, Kunizo; Masuda, Kikuo; Kiriyama, Noriki; Nitta, Keiichi; Yamamoto, Yuzuru; Shimizu, Sakae (Fac. Pharm. Sci., Kanazawa Univ., Kanazawa 920, Japan). Chem. Pharm. Bull., 29(4), 961-9 (English) 1981.

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Aspergillus fumigatus Fresen

Aspergillus fumigatus Fresen
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920

Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
Aspergillus cretensis

Conidia
Aspergillus cretensis

Seven-day-old cultures on CYA
Aspergillus cretensis

Conidiophores
Aspergillus clavatus

A colour enhanced image.
Cerebral aspergillosis – CT scans, CLL patient DS.

Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.

Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.

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