Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Asterriquinone A4
Copyright: n/a
Notes:
Species: A. terreusSystematic name: 2,5-Cyclohexadiene-1,4-dione, 2-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]-5-[2-(1,1-dimethyl-2-propenyl)-7-(3-methyl-2-butenyl)-1H-indol-3-yl]-3,6-dimethoxy-Molecular formulae: C39H42N2O4Molecular weight: 602Chemical abstracts number: 78723-16-7Selected references: Arai, Kunizo; Masuda, Kikuo; Kiriyama, Noriki; Nitta, Keiichi; Yamamoto, Yuzuru; Shimizu, Sakae (Fac. Pharm. Sci., Kanazawa Univ., Kanazawa 920, Japan). Chem. Pharm. Bull., 29(4), 961-9 (English) 1981.
Images library
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The chest x-ray shows a patient who had a left lung transplanted in May 2003 for cryptogenic fibrosing alveolitis, which was diagnosed post-transplant as sarcoidosis.
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Gross pathology demonstrating the great pleural thickness and two cavities (upper lobe and superior segment of lower lobe) with fragments of fungal mass.
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Histopathological appearance of a fungus ball. Note a conidial head resulting from fungal exposure to the air.
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Histopathological appearance of a fungus ball caused by Scedosporium apiospermum. The presence of anneloconidia differentiates it from Aspergillus.
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Chronic necrotising aspergillosis. Hyaline hyphal and calcium oxalate crystals obtained by needle aspirate biopsy from a diabetic patient with chronic necrotizing aspergillosis caused by Aspergillus niger (Papanicolaou, x 100).
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Aspergillus niger fungus ball and acute oxalosis. Higher magnification of adjacent replicate section.
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Oxalate crystals within renal tubuli (H&E, phase contrast, x 100). This patient developed acute oxalosis.
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Lung surface. Fungus ball, severe parenchymal fibrosis and pleural thickening.
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