Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Antibiotic 704II, tetronic acid derivative
Copyright: n/a
Notes:
Species: A. panamensisSystematic name: 3(2H)-Furanone, 2-(1,3-hexadienyl)-5-methoxy-4-(3-methoxy-1-oxobutyl)-2-methyl-Molecular formulae: C17H24O5Molecular weight: 308Chemical abstracts number: 75916-46-0Selected references: Metabolic products of microorganisms. 197. Investigations on metabolites of microorganisms. 23. Tetronic acid derivatives from Aspergillus panamensis. Production, isolation, characterization and biological activity. Anke, H.; Schwab, H.; Achenbach, H. Inst. Biol. II, Univ. Tuebingen, Tuebingen, Fed. Rep. Ger. Journal of Antibiotics (1980), 33(9), 931-9.
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Mr RM is 80 and an ex-coal miner.He developed pneumoconiosis from exposure to coal dust. He also developed rheumatoid arthritis and the combination of this disease and pneumoconiosis is called Caplan’s syndrome.
His chest Xray in early 2015 shows extensive bilateral pulmonary shadowing with solid looking nodules superimposed on abnormal lung fields, contraction of his left lung with an elevated diaphragm and a large left upper lobe aspergilloma, displaying a classic air crescent. His CT scan from mid 2014 demonstrates a large aspergilloma in a cavity on the left, with marked pleural thickening around it, which is partially ‘calcified’ towards its base. Inferiorly on other images,remarkable pleural thickening and fibrotic irregular and spiculated nodules are seen, most partially calcified.
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