Secondary metabolites, structure diagram: Trivial name - Anditomin

Date: 26 November 2013

Secondary metabolites, structure diagram: Trivial name – Anditomin

Notes:

Species: A. stellatusSystematic name: 9,15-Methano-3H,11H,13H-furo[3′,4′:3a,4]indeno[1,7a-g][2]benzoxepin-3,11,16-trione, 5,5a,6,7,8,9,10,10a,14,15,15a,15b-dodecahydro-5,5,9,15b-tetramethyl-14-methylene-, (5aR,7aS,9R,10aS,13aS,15R,15aR,15bR)-Molecular formulae: C25H30O5Molecular weight: 410Chemical abstracts number: 79874-93-4Selected references: Simpson, Thomas J.; Walkinshaw, Malcolm D. (Dep. Chem., Univ. Edinburgh, Edinburgh EH9 3JJ, Scot.). J. Chem. Soc., Chem. Commun., (17), 914-15 (English) 1981.

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Aspergillus fumigatus Fresen

Aspergillus fumigatus Fresen
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920

Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
Aspergillus cretensis

Conidia
Aspergillus cretensis

Seven-day-old cultures on CYA
Aspergillus cretensis

Conidiophores
Aspergillus clavatus

A colour enhanced image.
Cerebral aspergillosis – CT scans, CLL patient DS.

Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.

Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.

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