Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – Andilesin C
Copyright: n/a
Notes:
Species: A. stellatusSystematic name: 5,14a-Methano-1H,14aH-furo[3′,4′:4b,5]fluoreno[2,1-c]oxepin-3,6,10(5H)-trione, 4,5,6a,7,7a,7b,12,12a,13,14-decahydro-5,6a,7b,12,12-pentamethyl-, (3aS,5R,6aR,7aS,7bR,12aR,14aS,14bR)-Molecular formulae: C25H32O5Molecular weight: 410Chemical abstracts number: 72676-00-7Selected references: Dunn, Andrew W.; Johnstone, Robert A. W.; King, Trevor J.; Lessinger, Leslie; Sklarz, Benjamin (Robert Robinson Lab., Univ. Liverpool, Liverpool L69 3BX, Engl.). J. Chem. Soc., Perkin Trans. 1, (9), 2113-17 (English) 1979.
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Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
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Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.
Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.
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![Asp[1]niger](https://www.aspergillus.org.uk/wp-content/uploads/2013/11/Asp1niger-150x150.gif "Asp[1]niger")
