Secondary metabolites, structure diagram: Trivial name - andibenin

Date: 26 November 2013

Secondary metabolites, structure diagram: Trivial name – andibenin

Notes:

Species: A. stellatusSystematic name: Spiro[5,11a-methano-1H,11aH-fluoreno[4,4a-c]furan-9(3H),3′(6’H)-[2H]pyran]-3,6,6′(5H)-trione, 6a,7,7a,8,10,11-hexahydro-8-hydroxy-2′,2′,5,6a,8-pentamethyl-, (3’S,5S,6aR,7aR,8R,11aS,11bR)-Molecular formulae: C25H30O6Molecular weight: 426Chemical abstracts number: 60451-42-5Selected references: Holker, John S. E.; Simpson, Thomas J. (Robert Robinson Lab., Univ. Liverpool, Liverpool, Engl.). J. Chem. Soc., Chem. Commun., (14), 626-7 (English) 1978.

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Aspergillus fumigatus Fresen

Aspergillus fumigatus Fresen
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920

Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
Aspergillus cretensis

Conidia
Aspergillus cretensis

Seven-day-old cultures on CYA
Aspergillus cretensis

Conidiophores
Aspergillus clavatus

A colour enhanced image.
Cerebral aspergillosis – CT scans, CLL patient DS.

Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.

Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.

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